2026-04-13T04:57:57Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/1357382025-11-19T11:05:08Zcom_2072_1057col_2072_478917col_2072_478924
RECERCAT author Dragsted, Lars O. author Gao, Qian author Scalbert, Augustin author Vergères, Guy author Kolehmainen, Marjukka author Manach, Claudine author Brennan, Lorraine author Afman, Lydia A. author Wishart, David S. author Andrés Lacueva, Ma. Cristina author Garcia Aloy, Mar author Verhagen, Hans author Feskens, Edith J. M. author Praticò, Giulia 2019-06-21T09:15:58Z2019-06-21T09:15:58Z2018-05-302019-06-21T09:15:58Z Biomarkers of food intake (BFIs) are a promising tool for limiting misclassification in nutrition research where more subjective dietary assessment instruments are used. They may also be used to assess compliance to dietary guidelines or to a dietary intervention. Biomarkers therefore hold promise for direct and objective measurement of food intake. However, the number of comprehensively validated biomarkers of food intake is limited to just a few. Many new candidate biomarkers emerge from metabolic profiling studies and from advances in food chemistry. Furthermore, candidate food intake biomarkers may also be identified based on extensive literature reviews such as described in the guidelines for Biomarker of Food Intake Reviews (BFIRev). To systematically and critically assess the validity of candidate biomarkers of food intake, it is necessary to outline and streamline an optimal and reproducible validation process. A consensus-based procedure was used to provide and evaluate a set of the most important criteria for systematic validation of BFIs. As a result, a validation procedure was developed including eight criteria, plausibility, dose-response, time-response, robustness, reliability, stability, analytical performance, and inter-laboratory reproducibility. The validation has a dual purpose: (1) to estimate the current level of validation of candidate biomarkers of food intake based on an objective and systematic approach and (2) to pinpoint which additional studies are needed to provide full validation of each candidate biomarker of food intake. This position paper on biomarker of food intake validation outlines the second step of the BFIRev procedure but may also be used as such for validation of new candidate biomarkers identified, e.g., in food metabolomic studies. cc-by (c) Dragsted, Lars O. et al., 2018 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess Marcadors bioquímics Nutrició Metabòlits Biochemical markers Nutrition Metabolites Validation of biomarkers of food intake¿critical assessment of candidate biomarkers info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion