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urn:hdl:2445/135124 A role for the host in the roadmap to diabetes stem cell therapy Soria, Bernat Montanya Mias, Eduard Martin, Franz Hmadcha, Abdelkrim Diabetis Cèl·lules mare Teràpia cel·lular Diabetes Stem cells Cellular therapy Stem cells represent an unlimited source for cell therapy (1), and considerable efforts have been made to overcome barriers to introducing this revolutionary therapy into clinical practice. Briefly, the following actions must be taken: 1) design in vitro differentiation strategies to generate either mature postmitotic b-cells or b-cell progenitors that may be safely implanted into the host (e.g., without uncontrolled proliferation), 2) devise selection methods to produce a pure b-cell population, 3) validate standard characterization protocols to determine the real differentiation stage of the cells ready to be transplanted, 4) obtain encapsulation devices to implant the cells, 5) develop preclinical controls in representative animal models, and 6) de fine cell-host interactions (for a recent review see ref. 2) 2019-06-14T15:27:06Z 2019-06-14T15:27:06Z 2016-05 2019-06-14T15:27:06Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: https://doi.org/10.2337/dbi16-0003 Diabetes, 2016, vol. 65, num. 5, p. 1155-1157 https://doi.org/10.2337/dbi16-0003 cc-by-nc-nd (c) American Diabetes Association, 2016 http://creativecommons.org/licenses/by-nc-nd/3.0/es info:eu-repo/semantics/openAccess American Diabetes Association Articles publicats en revistes (Ciències Clíniques)