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Gastrin treatment stimulates beta cell regeneration and improves glucose tolerance in 95% pancreatectomized rats Téllez i Besolí, Noèlia Joanny Ordóñez, Géraldine Escoriza, Jessica Vilaseca Barceló, Marina Montanya Mias, Eduard Gastrina Cèl·lules B Glucosa Tolerància Ús terapèutic Gastrin B cells Glucose Toleration Therapeutic use β-Cell mass reduction is a central aspect in the development of type 1 and type 2 diabetes, and substitution or regeneration of the lost β-cells is a potentially curative treatment of diabetes. To study the effects of gastrin on β-cell mass in rats with 95% pancreatectomy (95%-Px), a model of pancreatic regeneration, rats underwent 95% Px or sham Px and were treated with [15 leu] gastrin-17 (Px+G and S+G) or vehicle (Px+V and S+V) for 15 d. In 95% Px rats, gastrin treatment reduced hyperglycemia (280 ± 52 mg vs. 436 ± 51 mg/dl, P < 0.05), and increased β-cell mass (1.15 ± 0.15 mg)) compared with vehicle-treated rats (0.67 ± 0.15 mg, P < 0.05). Gastrin treatment induced β-cell regeneration by enhancing β-cell neogenesis (increased number of extraislet β-cells in Px+G: 0.42 ± 0.05 cells/mm(2) vs. Px+V: 0.27 ± 0.07 cells/mm(2), P < 0.05, and pancreatic and duodenal homeobox 1 expression in ductal cells of Px+G: 1.21 ± 0.38% vs. Px+V: 0.23 ± 0.10%, P < 0.05) and replication (Px+G: 1.65 ± 0.26% vs. S+V: 0.64 ± 0.14%; P < 0.05). In addition, reduced β-cell apoptosis contributed to the increased β-cell mass in gastrin-treated rats (Px+G: 0.07 ± 0.02%, Px+V: 0.23 ± 0.05%; P < 0.05). Gastrin action on β-cell regeneration and survival increased β-cell mass and improved glucose tolerance in 95% Px rats, supporting a potential role of gastrin in the treatment of diabetes. 2019-06-03T14:08:16Z 2019-06-03T14:08:16Z 2011-07 2019-06-03T14:08:17Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 0013-7227 https://hdl.handle.net/2445/134421 602773 21558313 eng Reproducció del document publicat a: https://doi.org/10.1210/en.2011-0066 Endocrinology, 2011, vol. 152, num. 7, p. 2580-2588 https://doi.org/10.1210/en.2011-0066 (c) Association for the Study of Internal Secretions, 2011 info:eu-repo/semantics/openAccess 9 p. application/pdf application/pdf Association for the Study of Internal Secretions Articles publicats en revistes (Ciències Clíniques)