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oai:recercat.cat:2445/1342852025-12-05T13:15:57Zcom_2072_1057col_2072_478798col_2072_478816col_2072_478916col_2072_478917

A randomised study on the clinical progress of high-risk elective major gastrointestinal surgery patients treated with olive oil-based parenteral nutrition with or without a fish oil supplement Badia Tahull, Maria Bella Llop Talaverón, Josep Manuel Leiva Badosa, Elisabet Biondo, Sebastián Farrán Teixidor, Leandre Ramon Torrell, Josep M. (Josep Maria) Jódar Masanés, Ramón José Agents antiinfecciosos Cirurgia Malalties del tracte gastrointestinal Alimentació parenteral Ús terapèutic Emulsions Olis de peix Cura postoperatòria Programes de prevenció Anti-infective agents Surgery Gastrointestinal system diseases Parenteral feeding Therapeutic use Emulsions Fish oils Postoperative care Prevention programs n-3 Fatty acids have clinical benefits. The primary aim of the present study was the assessment of infection in patients who underwent major high-risk elective gastrointestinal surgery receiving postoperatively fish oil (FO)-supplemented parenteral nutrition (PN), compared with those receiving a standard olive oil (OO) emulsion. The secondary aims were the assessment of anti-inflammatory response and evaluation of tolerance and safety of these emulsions. A prospective, randomised, double-blind study was performed in patients requiring at least 5 d of PN. An isoenergetic and isoproteic formula was administered: group A received OO alone, while group B received OO that was partially replaced with FO (16.6 %, w/w). End points were outcome measures (mortality, sepsis, infection, hospitalisation days and PN duration), inflammatory response (C-reactive protein (CRP), prealbumin and leucocytes) and safety (TAG and glucose metabolism, and liver and kidney function). Statistical analysis was done using Student's t test and Fisher's exact test (P < 0.05). Twenty-seven patients were evaluated, with thirteen patients receiving FO. In this group, a significantly lower incidence of infections was found (23.1 v. 78.6 %, P = 0.007). CRP, prealbumin and leucocytes were not significantly different between the groups. There were no differences in safety parameters. We conclude that high-risk surgical patients receiving FO-supplemented PN for 5 d present a lower incidence of infection. Emulsions were safe and well tolerated. 2019-05-31T13:25:35Z 2019-05-31T13:25:35Z 2010-09 2019-05-31T13:25:35Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 0007-1145 https://hdl.handle.net/2445/134285 589931 20350344 eng Reproducció del document publicat a: https://doi.org/10.1017/S0007114510001066 British Journal of Nutrition, 2010, vol. 104, num. 5, p. 737-741 https://doi.org/10.1017/S0007114510001066 (c) Cambridge University Press, 2010 info:eu-repo/semantics/openAccess 5 p. application/pdf Cambridge University Press Articles publicats en revistes (Ciències Clíniques)