2026-04-17T04:59:26Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1336112025-12-05T09:34:05Zcom_2072_1057col_2072_478799col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Bosch Presegué, Laia author Raurell Vila, Helena author Thackray, Joshua K. author Casal, Carmen author González Merino, Jessica author Kane-Goldsmith, Noriko author Vizoso, Miguel author Brown, Jeremy author Gómez, Antonio author Ausió, Juan author Zimmermann, Timo author Esteller, Manel author Schotta, Gunnar author Singh, Prim B. author Serrano, Laura author Vaquero García, Alejandro author 2019-05-21T16:42:27Z 2019-05-21T16:42:27Z 2017-11-27 2019-05-21T16:42:27Z HP1 is a structural component of heterochromatin. Mammalian HP1 isoforms HP1α, HP1β, and HP1γ play different roles in genome stability, but their precise role in heterochromatin structure is unclear. Analysis of Hp1α-/-, Hp1β-/-, and Hp1γ-/- MEFs show that HP1 proteins have both redundant and unique functions within pericentric heterochromatin (PCH) and also act globally throughout the genome. HP1α confines H4K20me3 and H3K27me3 to regions within PCH, while its absence results in a global hyper-compaction of chromatin associated with a specific pattern of mitotic defects. In contrast, HP1β is functionally associated with Suv4-20h2 and H4K20me3, and its loss induces global chromatin decompaction and an abnormal enrichment of CTCF in PCH and other genomic regions. Our work provides insight into the roles of HP1 proteins in heterochromatin structure and genome stability. Genoma humà Heterocromatina Proteïnes Human genome Heterochromatin Proteins Mammalian HP1 isoforms have specific roles in heterochromatin structure and organization