2026-04-18T04:43:36Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1335982025-12-04T19:36:17Zcom_2072_1057col_2072_478813col_2072_478917
A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats
Molinar Toribio, Eunice María
Fuguet i Jordà, Elisabet
Ramos Romero, Sara
Taltavull, Núria
Méndez, Lucía
Nogués, Maria Rosa
Medina, Isabel
Torres Simón, Josep Lluís
Pérez-Jiménez, Jara
Polifenols
Metabòlits
Dieta
Biodisponibilitat
Polyphenols
Metabolites
Diet
Bioavailability
Purpose Polyphenol metabolites are key mediators of the biological activities of polyphenols. This study aimed to evaluate the long-term effects of a high-fat high-sucrose (HFHS) diet on the metabolism of proanthocyanidins from grape seed extract (GSE). Methods Adult female Wistar-Kyoto rats were fed a standard (STD) or HFHS diet supplemented or not with GSE for 16 weeks. PA metabolites were determined by targeted HPLC-MS/MS analysis. Results A lower concentration of total microbial-derived PA metabolites was present in urine and the aqueous fraction of faeces in the HFHS + GSE group than in the STD + GSE group. In contrast, a tendency towards the formation of conjugated (epi)catechin metabolites in the HFHS + GSE group was observed. Conclusions These results show that a HFHS diet significantly modifies PA metabolism, probably via: (1) a shift in microbial communities not counteracted by the polyphenols themselves; and (2) an up-regulation of hepatic enzymes.
2019-05-21T12:44:58Z
2019-05-21T12:44:58Z
2018-02
2019-05-21T12:44:58Z
info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
1436-6207
https://hdl.handle.net/2445/133598
667125
eng
Versió postprint del document publicat a: https://doi.org/10.1007/s00394-016-1323-9
European Journal of Nutrition, 2018, vol. 57, p. 339-349
https://doi.org/10.1007/s00394-016-1323-9
(c) Springer Verlag, 2018
info:eu-repo/semantics/openAccess
11 p.
application/pdf
Springer Verlag
Articles publicats en revistes (Enginyeria Química i Química Analítica)