2026-04-17T02:19:55Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1335982025-12-04T19:36:17Zcom_2072_1057col_2072_478813col_2072_478917
RECERCAT
author
Molinar Toribio, Eunice María
author
Fuguet i Jordà, Elisabet
author
Ramos Romero, Sara
author
Taltavull, Núria
author
Méndez, Lucía
author
Nogués, Maria Rosa
author
Medina, Isabel
author
Torres Simón, Josep Lluís
author
Pérez-Jiménez, Jara
2019-05-21T12:44:58Z2019-05-21T12:44:58Z2018-022019-05-21T12:44:58Z
Purpose Polyphenol metabolites are key mediators of the biological activities of polyphenols. This study aimed to evaluate the long-term effects of a high-fat high-sucrose (HFHS) diet on the metabolism of proanthocyanidins from grape seed extract (GSE). Methods Adult female Wistar-Kyoto rats were fed a standard (STD) or HFHS diet supplemented or not with GSE for 16 weeks. PA metabolites were determined by targeted HPLC-MS/MS analysis. Results A lower concentration of total microbial-derived PA metabolites was present in urine and the aqueous fraction of faeces in the HFHS + GSE group than in the STD + GSE group. In contrast, a tendency towards the formation of conjugated (epi)catechin metabolites in the HFHS + GSE group was observed. Conclusions These results show that a HFHS diet significantly modifies PA metabolism, probably via: (1) a shift in microbial communities not counteracted by the polyphenols themselves; and (2) an up-regulation of hepatic enzymes.
(c) Springer Verlag, 2018 info:eu-repo/semantics/openAccess
Polifenols
Metabòlits
Dieta
Biodisponibilitat
Polyphenols
Metabolites
Diet
Bioavailability
A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion