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Cooperative force generation of KIF1A Brownian motors Oriola Santandreu, David Casademunt i Viader, Jaume Proteïnes quinases Monòmers Protein kinases Monomers KIF1A is a kinesin motor protein that can work processively in a monomeric (single-headed) form by using a noise-driven ratchet mechanism. Here, we show that the combination of a passive diffusive state and finite-time kinetics of adenosine triphosphate hydrolysis provides a powerful mechanism of cooperative force generation, implying for instance that ∼ 10 monomeric KIF1As can team up to become ∼ 100 times stronger than a single one. Consequently, we propose that KIF1A could outperform conventional (double-headed) kinesin collectively and thus explain its specificity in axonal trafficking. We elucidate the cooperativity mechanism with a lattice model that includes multiparticle transitions. 2019-05-16T13:36:15Z 2019-05-16T13:36:15Z 2013-07-26 2019-05-16T13:36:15Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 0031-9007 https://hdl.handle.net/2445/133320 629651 eng Reproducció del document publicat a: https://doi.org/10.1103/PhysRevLett.111.048103 Physical Review Letters, 2013, vol. 111, num. 4, p. 048103 https://doi.org/10.1103/PhysRevLett.111.048103 (c) American Physical Society, 2013 info:eu-repo/semantics/openAccess 5 p. application/pdf application/pdf American Physical Society Articles publicats en revistes (Física de la Matèria Condensada)