2026-04-18T05:16:54Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1328742025-12-04T22:34:19Zcom_2072_1057col_2072_478917col_2072_478931

00925njm 22002777a 4500 dc Jiménez, Karen M. author Pereira Morales, Angela J. author Adan Puig, Ana author López Leon, Sandra author Forero, Diego A. author 2019-05-09T09:40:45Z 2019-05-09T09:40:45Z 2018-09-21 2019-05-09T09:40:45Z Genetic studies of major depressive disorder and its associated endophenotypes are useful for the identification of candidate genes. In recent years, variations in non-coding RNA genes, such as miRNAs, have been explored as novel candidates for psychiatric disorders and related endophenotypes. The aim of the present study was to evaluate the possible association between a functional polymorphism (rs12720208) in the FGF20 gene, which regulates its modulation by miR-433, and depressive symptoms in young adults. A sample of 270 participants from Colombia were evaluated with the Hospital Anxiety and Depression Scale - Depression Subscale (HADS-D) and genotyped for the rs12720208 polymorphism using a TaqMan assay. A lineal regression analysis was used. A statistically significant association of the functional polymorphism in the FGF20 gene (rs12720208) with depressive symptoms was found. It was observed that individuals with the G/A genotype had higher scores for the HADS-D subscale. Our results are the first description in the scientific literature about a significant association between a functional polymorphism in the FGF20 gene, which regulates its modulation by miR-433, and depressive symptoms. Depressió psíquica Salut mental Micro RNAs Gens Mental depression Mental health MicroRNAs Genes Depressive symptoms are associated with a functional polymorphism in a miR-433 binding site in the FGF20 gene