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Diastereoselective and catalytic α-alkylation of chiral N-acyl thiazolidinethiones with stable carbocationic salts Kennington, Stuart C. D. Ferré, Laura Romo Fernández, Juan Manuel Romea, Pedro Urpí Tubella, Fèlix Font Bardia, Ma. Mercedes Catàlisi Níquel Quiralitat Catalysis Nickel Chirality Direct nickel-catalyzed alkylation of chiral N-acyl-4-isopropyl-1,3-thiazolidine-2-thiones using a commercially available nickel(II) complex, (Me3P)2NiCl2, has been developed for tropylium and trityl tetrafluoroborate salts. The reaction provides a single diastereomer of the corresponding adducts in good to high yields, which, in turn, can be easily converted into a wide array of enantiomerically pure compounds that are difficult to obtain by other asymmetric procedures. 2019-03-04T15:22:32Z 2019-03-04T15:22:32Z 2017-06-15 2019-03-04T15:22:32Z info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Versió postprint del document publicat a: https://doi.org/10.1021/acs.joc.7b00657 Journal of Organic Chemistry, 2017, vol. 82, num. 12, p. 6426-6433 https://doi.org/10.1021/acs.joc.7b00657 (c) American Chemical Society , 2017 info:eu-repo/semantics/openAccess American Chemical Society Articles publicats en revistes (Química Inorgànica i Orgànica)