2026-04-17T20:22:10Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1294462025-12-05T14:54:02Zcom_2072_1057col_2072_478917col_2072_478924

00925njm 22002777a 4500 dc Hurtado Barroso, Sara author Quifer Rada, Paola author Rinaldi de Alvarenga, José Fernando author Pérez-Fernández, Silvia author Tresserra i Rimbau, Anna author Lamuela Raventós, Rosa Ma. author 2019-03-01T13:43:46Z 2019-03-01T13:43:46Z 2018-11-14 2019-03-01T13:43:47Z Abstract: Bioactive dietary compounds play a critical role in health maintenance. The relation between bioactive compound intake and cardiovascular health-related biomarkers has been demonstrated in several studies, although mainly with participants who have altered biochemical parameters (high blood pressure, high cholesterol, metabolic syndrome, etc.). The aim of this study was to evaluate if adopting a diet low in polyphenol-rich food for two weeks would affect vascular biomarkers in healthy men. In a crossover study, 22 healthy men were randomly assigned to their usual diet (UD), consuming healthy food rich in polyphenols, or to a low antioxidant diet (LAD), with less than two servings of fruit and vegetables per day and avoiding the intake of cocoa products, coffee and tea. As a marker of compliance, total polyphenols in urine were significantly lower after the LAD than after the UD (79 ± 43 vs. 123 ± 58 mg GAE/g creatinine). Nitric oxide levels were also reduced (52 ± 28 in LAD vs. 80 ± 34 µM in UD), although no significant changes in cellular adhesion molecules and eicosanoids were observed; however, an increasing ratio between thromboxane A2 (TXA2) and prostaglandin I2 (PGI2) was reached (p = 0.048). Thus, a slight dietary modification, reducing the consumption of polyphenol-rich food, may affect vascular biomarkers even in healthy individuals. Keywords: bioactive compounds; nitric oxide; vascular biomarkers; low antioxidant diet; Mediterranean diet; eicosanoids; adhesion molecules Compostos bioactius vegetals Òxid nítric Marcadors bioquímics Antioxidants Cuina mediterrània Icosanoides Plant bioactive compounds Nitric oxide Biochemical markers Antioxidants Mediterranean cooking Eicosanoids Changing to a Low-Polyphenol Diet Alters Vascular Biomarkers in Healthy Men after Only Two Weeks