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RECERCAT author Barrett, Jennifer H. author Iles, Mark M. author Harland, Mark author Taylor, John C. author Aitken, Joanne F. author Andresen, Per Arne author Akslen, Lars A. author Armstrong, Bruce K. author Avril, Marie F. author Azizi, Esther author Bakker, Bert author Bergman, Wilma author Bianchi Scarrà, Giovanna author Bressac-de Paillerets, Brigitte author Calista, Donato author Cannon-Albright, Lisa A. author Corda, Eve author Cust, Anne E. author Dębniak, Tadeusz author Duffy, David author Dunning, Alison M. author Easton, Douglas F. author Friedman, Eitan author Galan, Pilar author Ghiorzo, Paola author Giles, Graham G. author Hansson, Johan author Hocevar, Marko author Höiom, Veronica author Hopper, John L. author Ingvar, Christian author Janssen, Bart author Jenkins, Mark A. author Jönsson, Göran author Kefford, Richard F. author Landi, Giorgio author Landi, Maria Teresa author Lang, Julie author Lubinski, Jan author Mackie, Rona author Malvehy, J. (Josep) author Martin, Nicholas G. author Molven, Anders author Montgomery, Grant W. author Nieuwpoort, Frans A. van author Novakovic, Srdjan author Olsson, Håkan author Pastorino, Lorenza author Puig i Sardà, Susana author Puig Butillé, Joan Anton author Randerson-Moor, Juliette author Snowden, Helen author Tuominen, Raider author Belle, Patricia van author Stoep, Nienke van der author Whiteman, David C. author Zelenika, Diana author Han, Jiali author Fang, Shenying author Lee, Jeffrey E. author Wei, Qingyi author Lathrop, Mark author Gillanders, Elizabeth M. author Brown, Kevin M. author Goldstein, Alisa M. author Kanetsky, Peter A. author Mann, Graham J. author MacGregor, Stuart author Elder, David E. author Amos, Christopher I. author Hayward, Nicholas K. author Gruis, Nelleke A. author Demenais, Florence author Newton-Bishop, Julia A. author Bishop, D. Timothy author GenoMEL Consortium 2019-02-25T16:04:31Z2019-02-25T16:04:31Z2011-10-092019-02-25T16:04:31Z We report a genome-wide association study for melanoma that was conducted by the GenoMEL Consortium. Our discovery phase included 2,981 individuals with melanoma and 1,982 study-specific control individuals of European ancestry, as well as an additional 6,426 control subjects from French or British populations, all of whom were genotyped for 317,000 or 610,000 single-nucleotide polymorphisms (SNPs). Our analysis replicated previously known melanoma susceptibility loci. Seven new regions with at least one SNP with P < 10−5 and further local imputed or genotyped support were selected for replication using two other genome-wide studies (from Australia and Texas, USA). Additional replication came from case-control series from the UK and The Netherlands. Variants at three of the seven loci replicated at P < 10−3: an SNP in ATM (rs1801516, overall P = 3.4 × 10−9), an SNP in MX2 (rs45430, P = 2.9 × 10−9) and an SNP adjacent to CASP8 (rs13016963, P = 8.6 × 10−10). A fourth locus near CCND1 remains of potential interest, showing suggestive but inconclusive evidence of replication (rs1485993, overall P = 4.6 × 10−7 under a fixed-effects model and P = 1.2 × 10−3 under a random-effects model). These newly associated variants showed no association with nevus or pigmentation phenotypes in a large British case-control series. (c) Barrett, Jennifer H. et al., 2011 info:eu-repo/semantics/openAccess Melanoma Genètica mèdica Càncer de pell Melanoma Medical genetics Skin cancer Genome-wide association study identifies three new melanoma susceptibility loci info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion