2026-04-13T04:14:13Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1281982025-12-05T14:25:28Zcom_2072_1057col_2072_478816col_2072_478917

Synthesis of a-chlorolactams by cyanoborohydride-mediated radical cyclization of trichloroacetamides Coussanes, Guilhem Jakobi, Harald Lindell, Stephen Bonjoch i Sesé, Josep Lactames Herbicides Radicals (Química) Síntesi orgànica Lactams Herbicides Radicals (Chemistry) Organic synthesis A cyanoborohydride-promoted radical cyclization methodology has been developed to access α-chlorolactams in a simple and efficient way, using NaBH3CN and trichloroacetamides easily available from allylic and homoallylic secondary amines. This methodology allowed the synthesis of a library of αchlorolactams (mono and bicyclic), which were tested for herbicidal activity, trans-3-chloro-4-methyl-1-(3-trifluoromethyl)phenyl-2-pyrrolidinone being the most active. 2019-02-13T11:17:03Z 2019-05-16T05:10:17Z 2018-05-16 2019-02-13T11:17:03Z info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Versió postprint del document publicat a: https://doi.org/10.1002/chem.201800210 Chemistry-A European Journal, 2018, vol. 24, num. 32, p. 8151-8156 https://doi.org/10.1002/chem.201800210 (c) Wiley-VCH, 2018 info:eu-repo/semantics/openAccess Wiley-VCH Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)