2026-04-13T07:11:07Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1272562025-12-05T09:22:36Zcom_2072_1057col_2072_478799col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Delgado Morales, Raul author Agís Balboa, Roberto Carlos author Esteller, Manel author Berdasco, María author 2019-01-15T08:54:36Z 2019-01-15T08:54:36Z 2017-06-29 2019-01-15T08:54:36Z Ageing is the main risk factor for human neurological disorders. Among the diverse molecular pathways that govern ageing, epigenetics can guide age-associated decline in part by regulating gene expression and also through the modulation of genomic instability and high-order chromatin architecture. Epigenetic mechanisms are involved in the regulation of neural differentiation as well as in functional processes related to memory consolidation, learning or cognition during healthy lifespan. On the other side of the coin, many neurodegenerative diseases are associated with epigenetic dysregulation. The reversible nature of epigenetic factors and, especially, their role as mediators between the genome and the environment make them exciting candidates as therapeutic targets. Rather than providing a broad description of the pathways epigenetically deregulated in human neurological disorders, in this review, we have focused on the potential use of epigenetic enzymes as druggable targets to ameliorate neural decline during normal ageing and especially in neurological disorders. We will firstly discuss recent progress that supports a key role of epigenetic regulation during healthy ageing with an emphasis on the role of epigenetic regulation in adult neurogenesis. Then, we will focus on epigenetic alterations associated with ageing-related human disorders of the central nervous system. We will discuss examples in the context of psychiatric disorders, including schizophrenia and posttraumatic stress disorders, and also dementia or Alzheimer's disease as the most frequent neurodegenerative disease. Finally, methodological limitations and future perspectives are discussed. Epigenètica ADN Metilació Neurobiologia del desenvolupament Envelliment cerebral Neurones Cervell Epigenetics DNA Methylation Developmental neurobiology Aging brain Neurons Brain Epigenetic mechanisms during ageing and neurogenesis as novel therapeutic avenues in human brain disorders