2026-04-17T20:12:47Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1270862025-12-05T13:16:55Zcom_2072_1057col_2072_478798col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Santos Pérez, Salud author Marin, Alicia author Serra Batlles, Joan author Rosa, David de la author Solanes, Ingrid author Pomares, Xavier author López Sánchez, Marta author Muñoz Esquerre, Mariana author Miravitlles Fernández, Marc author 2018-12-20T12:48:47Z 2018-12-20T12:48:47Z 2016-03-11 2018-12-20T12:48:47Z Exacerbations of COPD represent an important medical and health care problem. Certain susceptible patients suffer recurrent exacerbations and as a consequence have a poorer prognosis. The effects of bronchial infection, either acute or chronic, and of the inflammation characteristic of the disease itself raise the question of the possible role of antibiotics and anti-inflammatory agents in modulating the course of the disease. However, clinical guidelines base their recommendations on clinical trials that usually exclude more severe patients and patients with more comorbidities, and thus often fail to reflect the reality of clinicians attending more severe patients. In order to discuss aspects of clinical practice of relevance to pulmonologists in the treatment and prevention of recurrent exacerbations in patients with severe COPD, a panel discussion was organized involving expert pulmonologists who devote most of their professional activity to day hospital care. This article summarizes the scientific evidence currently available and the debate generated in relation to the following aspects: bacterial and viral infections, chronic bronchial infection and its treatment with cyclic oral or inhaled antibiotics, inflammatory mechanisms and their treatment, and the role of computerized tomography as a diagnostic tool in patients with severe COPD and frequent exacerbations. Malalties pulmonars obstructives cròniques Inflamació Infeccions Chronic obstructive pulmonary diseases Inflammation Infections Treatment of patients with COPD and recurrent exacerbations: the role of infection and inflammation