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oai:recercat.cat:2445/1270152025-12-04T21:42:12Zcom_2072_1057col_2072_478917col_2072_478933

Direct Asymmetric Hydrogenation of N-Methyl and N-Alkyl Imines with an Ir(III)H Catalyst Salomó i Prat, Ernest Gallen Ortiz, Albert Sciortino, Giuseppe Ujaque, Gregori Grabulosa, Arnald Lledós, Agustí (Lledós i Falcó) Riera i Escalé, Antoni Verdaguer i Espaulella, Xavier Catàlisi asimètrica Lligands Hidrogenació Enantioselective catalysis Ligands Hydrogenation A novel cationic [IrH(THF)(P,N)(imine)] [BArF] catalyst contg. a P-stereogenic MaxPHOX ligand is described for the direct asym. hydrogenation of N-Me and N-alkyl imines. This is the first catalytic system to attain high enantioselectivity (up to 94% ee) in this type of transformation. The labile THF ligand allows for effective activation and reactivity, even at low temps. D. functional theory calcns. allowed the rationalization of the stereochem. course of the reaction. 2018-12-17T14:54:57Z 2019-11-26T06:10:15Z 2018-11-26 2018-12-17T14:54:58Z info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Versió postprint del document publicat a: https://doi.org/10.1021/jacs.8b11547 Journal of the American Chemical Society, 2018, vol. 140, p. 16967-16970 https://doi.org/10.1021/jacs.8b11547 (c) American Chemical Society , 2018 info:eu-repo/semantics/openAccess American Chemical Society Articles publicats en revistes (Química Inorgànica i Orgànica)