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oai:recercat.cat:2445/1266152025-12-05T12:18:45Zcom_2072_1057col_2072_478916col_2072_478917

Romiplostim in chronic liver disease with severe thrombocytopenia undergoing an elective invasive procedure Castellote Alonso, José Girbau, Anna Arajol, Claudia Xiol Quingles, Xavier Malalties del fetge Malalties cròniques Liver diseases Chronic diseases Letters to the Editor Dear Editor, Thrombocytopenia is a common complication seen in patients with chronic liver disease, precluding or interfering invasive diagnostic and therapeutic procedures. Etiology is multifactorial, including hypersplenism, bone marrow suppression by HCV and a possible reduction in the level or activity of the hematopoietic growth factor thrombopoietin (TPO)(1). In addition to thrombocytopenia, functional platelet defects has been suggested. Romiplostim (Nplate®, Amgen Inc, Thousands Oaks, Calif) is a new thrombopoietin receptor agonist indicated for the treatment of thrombocytopenia in patients with chronic immune thrombocytopenic purpura who have had an insufficient response to corticosteroids, immunoglobulin or splenectomy (2). It has been not tested in chronic liver disease until now. Another thrombopoietin receptor agonist, eltrombopag (3), has been tested in chronic liver disease undergoing an elective invasive procedure. Although results were satisfactory in terms of platetelet count and avoidance of platelet transfusions, the trial was early stopped due to the observed incidence of portal vein thrombosis in the study group (4). We report a case of a Jehovah’s Witness that could successfully managed with romiplostim use... 2018-11-30T10:16:04Z 2018-11-30T10:16:04Z 2011-10 2018-07-24T12:59:18Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion https://hdl.handle.net/2445/126615 spa Reproducció del document publicat a: https://doi.org/10.4321/S1130-01082011001000015 Revista Española de Enfermedades Digestivas, 2011, vol. 103, num. 10, p. 556-556 https://doi.org/10.4321/S1130-01082011001000015 (c) Aran Ediciones, 2011 info:eu-repo/semantics/openAccess 2 p. application/pdf Aran Ediciones Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))