2026-04-14T06:10:14Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1253592025-12-05T12:17:25Zcom_2072_1057col_2072_478916col_2072_478917
RECERCAT
author
Lesseur, Corina
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Diergaarde, Brenda
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Olshan, Andrew F.
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Wünsch-Filho, Victor
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Ness, Andrew R.
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Liu, Geoffrey
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Lacko, Martin
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Eluf Neto, José
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Franceschi, Silvia
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Lagiou, Pagona
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MacFarlane, Gary J.
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Richiardi, Lorenzo
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Boccia, Stefania
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Polesel, Jerry
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Kjaerheim, Kristina
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Zaridze, David
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Johansson, Mattias
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Menezes, Ana A.
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Curado, Maria Paula
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Robinson, Max
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Ahrens, Wolfgang
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Canova, Cristina
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Znaor, Ariana
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Castellsagué, Xavier
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Conway, David I.
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Holcátová, Ivana
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Mates, Dana
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Vidensky, Marta
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Healy, Claire M.
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Szeszenia-Dabrowska, Neonila
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Fabianova, Eleonora
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Lissowska, Jolanta
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Grandis, Jennifer R.
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Weissler, Mark C.
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Tajara, Eloiza H.
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Nunes, Fabio D.
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Carvalho, Marcos B. de
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Thomas, Steve
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Hung, Rayjean J.
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Peters, Wilbert H. M.
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Herrero, Rolando
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Cadoni, Gabriella
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Bueno de Mesquita, H. Bas
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Steffen, Annika
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Agudo, Antonio
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Shangina, Oxana
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Xiao, Xiangjun
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Gaborieau, Valérie
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Chabrier, Amélie
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Anantharaman, Devasena
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Boffetta, Paolo
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Amos, Christopher I.
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McKay, James D.
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Brennan, Paul
2018-10-16T13:04:47Z2018-10-16T13:04:47Z2016-12-012018-07-24T12:15:18Z
We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 x 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 x 10(-9)). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 x 10(-6)) than in HPV-negative (OR = 0.75, P = 0.16) cancers.
cc-by-nc-sa (c) Lesseur et al., 2016 http://creativecommons.org/licenses/by-nc-sa/3.0/es/ info:eu-repo/semantics/openAccess
Càncer de boca
Papil·lomavirus
Oral cancer
Papillomaviruses
Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion