2026-04-14T07:37:48Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1253592025-12-05T12:17:25Zcom_2072_1057col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Lesseur, Corina author Diergaarde, Brenda author Olshan, Andrew F. author Wünsch-Filho, Victor author Ness, Andrew R. author Liu, Geoffrey author Lacko, Martin author Eluf Neto, José author Franceschi, Silvia author Lagiou, Pagona author MacFarlane, Gary J. author Richiardi, Lorenzo author Boccia, Stefania author Polesel, Jerry author Kjaerheim, Kristina author Zaridze, David author Johansson, Mattias author Menezes, Ana A. author Curado, Maria Paula author Robinson, Max author Ahrens, Wolfgang author Canova, Cristina author Znaor, Ariana author Castellsagué, Xavier author Conway, David I. author Holcátová, Ivana author Mates, Dana author Vidensky, Marta author Healy, Claire M. author Szeszenia-Dabrowska, Neonila author Fabianova, Eleonora author Lissowska, Jolanta author Grandis, Jennifer R. author Weissler, Mark C. author Tajara, Eloiza H. author Nunes, Fabio D. author Carvalho, Marcos B. de author Thomas, Steve author Hung, Rayjean J. author Peters, Wilbert H. M. author Herrero, Rolando author Cadoni, Gabriella author Bueno de Mesquita, H. Bas author Steffen, Annika author Agudo, Antonio author Shangina, Oxana author Xiao, Xiangjun author Gaborieau, Valérie author Chabrier, Amélie author Anantharaman, Devasena author Boffetta, Paolo author Amos, Christopher I. author McKay, James D. author Brennan, Paul author 2018-10-16T13:04:47Z 2018-10-16T13:04:47Z 2016-12-01 2018-07-24T12:15:18Z We conducted a genome-wide association study of oral cavity and pharyngeal cancer in 6,034 cases and 6,585 controls from Europe, North America and South America. We detected eight significantly associated loci (P < 5 x 10(-8)), seven of which are new for these cancer sites. Oral and pharyngeal cancers combined were associated with loci at 6p21.32 (rs3828805, HLA-DQB1), 10q26.13 (rs201982221, LHPP) and 11p15.4 (rs1453414, OR52N2-TRIM5). Oral cancer was associated with two new regions, 2p23.3 (rs6547741, GPN1) and 9q34.12 (rs928674, LAMC3), and with known cancer-related loci-9p21.3 (rs8181047, CDKN2B-AS1) and 5p15.33 (rs10462706, CLPTM1L). Oropharyngeal cancer associations were limited to the human leukocyte antigen (HLA) region, and classical HLA allele imputation showed a protective association with the class II haplotype HLA-DRB1*1301-HLA-DQA1*0103-HLA-DQB1*0603 (odds ratio (OR) = 0.59, P = 2.7 x 10(-9)). Stratified analyses on a subgroup of oropharyngeal cases with information available on human papillomavirus (HPV) status indicated that this association was considerably stronger in HPV-positive (OR = 0.23, P = 1.6 x 10(-6)) than in HPV-negative (OR = 0.75, P = 0.16) cancers. Càncer de boca Papil·lomavirus Oral cancer Papillomaviruses Genome-wide association analyses identify new susceptibility loci for oral cavity and pharyngeal cancer