2026-04-18T07:42:51Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1249092025-11-19T20:55:56Zcom_2072_1057col_2072_478917col_2072_478933

Toward angiogenesis inhibitors based on the conjugation of organometallic platinum(II) complexes to RGD peptides Zamora, Ana Gandioso, Albert Massaguer i Vall-llovera, Anna Buenestado, Silvia Calvis, Carme Hernández, José Luis Mitjans, Francesc Rodríguez, Venancio Ruiz, José Marchán Sancho, Vicente Angiogènesi Càncer Pèptids Compostos organometàl·lics Neovascularization Cancer Peptides Organometallic compounds A novel conjugate between a cyclometalated platinum(II) complex with dual antiangiogenic and antitumor activity and a cyclic peptide containing the RGD sequence (-Arg-Gly-Asp-) has been synthesized by combining solid- and solution-phase methodologies. Although peptide conjugation rendered a non-cytotoxic compound in all tested tumor cell lines (± αV β3 and αV β5 integrin receptors), the antiangiogenic activity of the Pt-c(RGDfK) conjugate in human umbilical vein endothelial cells at sub-cytotoxic concentrations opens the way to the design of a novel class of angiogenesis inhibitors through conjugation of metallodrugs with high antiangiogenic activity to cyclic RGD-containing peptides or peptidomimetic analogues. 2018-09-28T08:26:46Z 2019-09-06T05:10:17Z 2018-09-06 2018-09-28T08:26:46Z info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion 1860-7179 https://hdl.handle.net/2445/124909 682200 29932312 eng Versió postprint del document publicat a: https://doi.org/10.1002/cmdc.201800282 ChemMedChem, 2018, vol. 13, num. 17, p. 1755-1762 https://doi.org/10.1002/cmdc.201800282 (c) Wiley-VCH, 2018 info:eu-repo/semantics/openAccess 8 p. application/pdf application/pdf Wiley-VCH Articles publicats en revistes (Química Inorgànica i Orgànica)