2026-04-17T01:42:53Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1230702025-12-05T14:14:52Zcom_2072_1057col_2072_478906col_2072_478917col_2072_478921col_2072_478931

00925njm 22002777a 4500 dc Ottino González, Jonatan author Jurado, Ma. Ángeles (María Ángeles) author García-García, Isabel author Segura i Fàbregas, Bàrbara author Marqués Iturria, Idoia author Sender Palacios, María José author Tor, Encarnació author Prats Soteras, Xavier author Caldú i Ferrús, Xavier author Junqué i Plaja, Carme, 1955- author Garolera i Freixa, Maite author 2018-06-18T14:03:22Z 2018-06-18T14:03:22Z 2017-12-22 2018-06-18T14:03:22Z Objective: Overweight (body mass index or BMI 25 kg/m2) and stress interact with each other in complex ways. Overweight promotes chronic low-inflammation states, while stress is known to mediate caloric intake. Both conditions are linked to several avoidable health problems and to cognitive decline, brain atrophy, and dementia. Since it was proposed as a framework for the onset of mental illness, the allostatic load model has received increasing attention. Although changes in health and cognition related to overweight and stress are well-documented separately, the association between allostatic load and brain integrity has not been addressed in depth, especially among overweight subjects. Method: Thirty-four healthy overweight-to-obese and 29 lean adults underwent blood testing, neuropsychological examination, and magnetic resonance imaging to assess the relationship between cortical thickness and allostatic load, represented as an index of 15 biomarkers (this is, systolic and diastolic arterial tension, glycated hemoglobin, glucose, creatinine, total cholesterol, HDL and LDL cholesterol, triglycerides, c-reactive protein, interleukin-6, insulin, cortisol, fibrinogen, and leptin). Results: Allostatic load indexes showed widespread positive and negative significant correlations (p < 0.01) with cortical thickness values depending on body-weight status. Conclusion: The increase of allostatic load is linked to changes in the gray matter composition of regions monitoring behavior, sensory-reward processing, and general cognitive function. Obesitat Estrès (Psicologia) Escorça cerebral Obesity Stress (Psychology) Cerebral cortex Allostatic Load Is Linked to Cortical Thickness Changes Depending on Body-Weight Status