2026-04-13T04:54:46Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1227192025-12-05T01:35:57Zcom_2072_1057col_2072_478917

Assessing the variability in transmission of bovine tuberculosis within Spanish cattle herds Ciaravino, Giovanna García Saenz, Ariadna Cabras, S. Allepuz, Alberto Casal, J. García-Bocanegra, Ignacio Koeijer, A. De Gubbins, S. Saez, J. L. Cano Terriza, D. Napp, Sebastian Tuberculosi en els animals Espanya Tuberculosis in animals Spain In Spain, despite years of efforts to eradicate bovine tuberculosis (bTB), the disease is still endemic, with some areas of high prevalence. In this context, the surveillance and control plans may need to be re-evaluated, and understanding the dynamics of bTB spread within Spanish herds may help to develop new strategies for reducing the time for detection of infected herds and for the elimination of bTB from the herds already infected. Here, we developed a compartmental stochastic model to simulate bTB within-herd transmission, fed it with epidemiological data from 22 herds (obtained from a previous work) and carried out parameter inference using Approximate Bayesian Computing methods We also estimated the "Within-herd transmission potential Number" (Rh), i.e. the average number of secondary cases generated by a single animal infected introduced into a totally susceptible herd, considering different scenarios depending on the frequency of controls. The median global values obtained for the transmission parameters were: for the transmission coefficient (beta), 0.014 newly infected animals per infectious individual per day (i.e. 5.2 per year), for the rate at which infected individuals become infectious (alpha), 0.01 per day (equivalent to a latent period of 97days), and for the rate at which infected individuals become reactive to the skin test (alpha1), 0.08 per day (equivalent to a period of 12days for an infected animal to become reactive). However, the results also evidenced a great variability in the estimates of those parameters (in particular beta and alpha) among the 22 herds. Considering a 6-month interval between tests, the mean Rh was 0.23, increasing to 0.82 with an interval of 1year, and to 2.01 and 3.47 with testing intervals of 2 and 4 years, respectively. 2018-06-01T13:25:05Z 2018-06-01T13:25:05Z 2018-06 2018-03-07T19:00:33Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: http://dx.doi.org/10.1016/j.epidem.2018.01.003 Epidemics, 2018, vol. 23, p. 110-120 http://dx.doi.org/10.1016/j.epidem.2018.01.003 cc by-nc-nd (c) Elsevier, 2018 http://creativecommons.org/licenses/by-nc-nd/3.0/es/ info:eu-repo/semantics/openAccess Elsevier Articles publicats en revistes (ISGlobal)