2026-04-17T00:34:43Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1225872025-12-04T21:14:04Zcom_2072_1057col_2072_478781col_2072_478917
RECERCAT
author
Moreno Guillén, Estefanía
author
Andradas, Clara
author
Medrano Moya, Mireia
author
Caffarel, María M.
author
Pérez-Gómez, Eduardo
author
Blasco-Benito, Sandra
author
Gómez-Cañas, María
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Pazos, M. Ruth
author
Irving, Andrew J.
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Lluís i Biset, Carme
author
Canela Campos, Enric I. (Enric Isidre), 1949-
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Fernández-Ruiz, Javier
author
Guzmán, Manuel
author
McCormick, Peter J.
author
Sánchez Mora, Cristina
2018-05-25T17:49:43Z2018-05-25T17:49:43Z2014-08-082018-05-25T17:49:43Z
The G protein-coupled receptors CB2 (CB2R) and GPR55 are overexpressed in cancer cells and human tumors. Because a modulation of GPR55 activity by cannabinoids has been suggested, we analyzed whether this receptor participates in cannabinoid effects on cancer cells. Here we show that CB2R and GPR55 form heteromers in cancer cells, that these structures possess unique signaling properties, and that modulation of these heteromers can modify the antitumoral activity of cannabinoids in vivo. These findings unveil the existence of previously unknown signaling platforms that help explain the complex behavior of cannabinoids and may constitute new targets for therapeutic intervention in oncology.
(c) American Society for Biochemistry and Molecular Biology, 2014 info:eu-repo/semantics/openAccess
Transducció de senyal cel·lular
Càncer
Cellular signal transduction
Cancer
Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion