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Maternal Smoking during Pregnancy and Early Childhood and Development of Asthma and Rhinoconjunctivitis - a MeDALL Project Thacher, Jesse D. Gehring, Ulrike Gruzieva, Olena Standl, Marie Pershagen, Göran Bauer, Carl-Peter Berdel, Dietrich Keller, Theresa Koletzko, Sibylle Koppelman, Gerard H. Kull, Inger Lau, Susanne Lehmann, Irina Maier, Dieter Schikowski, Tamara Wahn, Ulrich Wijga, Alet H. Heinrich, Joachim Bousquet, Jean Antó i Boqué, Josep Maria Berg, Andrea von Melén, Erik Smit, Henriette A. Keil, Thomas Bergstrom, Anna Embarassades Hàbit de fumar en l'embaràs Pregnant women Pregnant women BACKGROUND: The role of tobacco smoke exposure in the development and persistence of asthma and rhinoconjunctivitis through childhood into adolescence is unclear. OBJECTIVES: We assessed the associations of parental smoking from fetal life through adolescence with asthma and rhinoconjunctivitis during childhood and adolescence. METHODS: We analyzed data for 10,860 participants of five European birth cohort studies from the Mechanisms of the Development of Allergy (MeDALL) consortium. Parental smoking habits and health outcomes (early transient, persistent, and adolescent-onset asthma and rhinoconjunctivitis) were based on questionnaires covering the period from pregnancy to 14-16 y of age. Data were combined and analyzed using a one-stage and two-stage individual participant data meta-analysis. RESULTS: Overall, any maternal smoking during pregnancy tended to be associated with an increased odds of prevalent asthma [adjusted odds ratio (aOR)=1.19 (95% CI: 0.98, 1.43)], but not prevalent rhinoconjunctivitis [aOR=1.05 (95% CI: 0.90, 1.22)], during childhood and adolescence. In analyses with phenotypes related to age of onset and persistence of disease, any maternal smoking during pregnancy was associated with early transient asthma [aOR=1.79 (95% CI: 1.14, 2.83)]. Maternal smoking of >/=10 cigarettes/day during pregnancy was associated with persistent asthma [aOR=1.66 (95% CI: 1.29, 2.15)] and persistent rhinoconjunctivitis [aOR=1.55 (95% CI, 1.09, 2.20)]. Tobacco smoke exposure during fetal life, infancy, childhood, and adolescence was not associated with adolescent-onset asthma or rhinoconjunctivitis. CONCLUSIONS: Findings from this combined analysis of five European birth cohorts strengthen evidence linking early exposure to tobacco smoke with asthma during childhood and adolescence. Children with high early-life exposure were more likely than unexposed children to have early transient and persistent asthma and persistent rhinoconjunctivitis. https://doi.org/10.1289/EHP2738. 2018-05-08T12:25:31Z 2018-05-08T12:25:31Z 2018-04 2018-04-18T17:59:56Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: http://dx.doi.org/10.1289/EHP2738 Environmental Health Perspectives, 2018, vol. 126, num. 4, p. 047005-1-047005-13 http://dx.doi.org/10.1289/EHP2738 info:eu-repo/grantAgreement/EC/FP7/261357/EU//MEDALL Domini públic / Public domain http://creativecommons.org/publicdomain/mark/1.0/ info:eu-repo/semantics/openAccess National Institute of Environmental Health Sciences Articles publicats en revistes (ISGlobal)