2026-04-17T04:11:29Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1220552025-12-05T14:14:53Zcom_2072_1057col_2072_478906col_2072_478917col_2072_478931

00925njm 22002777a 4500 dc Adan Puig, Ana author Capella Arrondo, Maria del Mar author Prat, Gemma author Forero, Diego A. author López Vera, Silvia author Navarro Humanes, José Francisco author 2018-05-03T11:37:09Z 2018-05-03T11:37:09Z 2017-01-18 2018-05-03T11:37:09Z Background: Lifetime suicide attempts in patients with comorbidity between psychotic disorders and Substance Use Disorder (SUD), known as dual diagnosis, was associated with a worse clinical and cognitive state, poor prognosis and premature death. However, to date no previous study has examined the cognitive performance of these patients considering as independent the presence or absence of lifetime suicide attempts. Methods: We explore executive functioning differences between suicide attempters and non-attempters in dual schizophrenia (DS) patients and the possible related factors for both executive performance and current suicide risk. Fifty DS male patients in remission of SUD and clinically stables, 24 with and 26 without lifetime suicide attempts, were evaluated. We considered Z scores for all neuropsychological tests and a composite summary score for both premorbid IQ and executive functioning. Results: DS patients showed low performance in set-shifting, planning and problem solving tasks. Those with suicide attempts presented lower composite summary scores, together with worse problem solving skills and decision-making, compared with non-attempters. However, after controlling for alcohol dependence, only differences in decision-making remained. Executive functioning was related to the premorbid intelligence quotient, and several clinical variables (duration, severity, months of abstinence and relapses of SUD, global functioning and negative symptoms). A relationship between current suicide risk, and first-degree relatives with SUD, insight and positive symptoms was also found. Conclusions: Our results suggest that problem solving and, especially, decision-making tasks might be sensitive to cognitive impairment of DS patients related to presence of lifetime suicide attempts. The assessment of these executive functions and cognitive remediation therapy when necessary could be beneficial for the effectiveness of treatment in patients with DS. However, further research is needed to expand our findings and overcome some limitations of this study. Esquizofrènia Suïcidi Consum d'alcohol Schizophrenia Suicide Drinking of alcoholic beverages Executive functioning in men with schizophrenia and substance use disorders. Influence of Lifetime Suicide Attemps