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oai:recercat.cat:2445/1203952025-12-06T04:08:30Zcom_2072_1057col_2072_478798col_2072_478858col_2072_478916col_2072_478917col_2072_478921

00925njm 22002777a 4500 dc Salgado, Rocío author Servitje Bedate, Octavio author Gallardo, F. (Fernando) author Vermeer, Maarten H. author Ortiz Romero, Pablo Luis author Karpova, Maria B. author Zipser, Marie C. author Muniesa Montserrat, Cristina author Garcia-Muret, Maria P. author Estrach Panella, Ma. Teresa (María Teresa) author Salido Galeote, Marta author Sánchez Schmidt, Júlia author Herrera, Marta author Romagosa, Vicenç author Suela, Javier author Ferreira, Bibiana I. author Cigudosa, Juan Cruz author Barranco, Carlos author Serrano, Sergi author Dummer, Reinhard author Tensen, Cornelis P. author Solé Ristol, Francesc author Pujol, Ramon M. author Espinet Solà, Blanca author 2018-03-02T09:57:27Z 2018-03-02T09:57:27Z 2010-04 2018-03-02T09:57:27Z Mycosis fungoide (MF) patients who develop tumors or extracutaneous involvement usually have a poor prognosis with no curative therapy available so far. In the present European Organization for Research and Treatment of Cancer (EORTC) multicenter study, the genomic profile of 41 skin biopsies from tumor stage MF (MFt) was analyzed using a high-resolution oligo-array comparative genomic hybridization platform. Seventy-six percent of cases showed genomic aberrations. The most common imbalances were gains of 7q33.3q35 followed by 17q21.1, 8q24.21, 9q34qter, and 10p14 and losses of 9p21.3 followed by 9q31.2, 17p13.1, 13q14.11, 6q21.3, 10p11.22, 16q23.2, and 16q24.3. Three specific chromosomal regions, 9p21.3, 8q24.21, and 10q26qter, were defined as prognostic markers showing a significant correlation with overall survival (OS) (P=0.042, 0.017, and 0.022, respectively). Moreover, we have established two MFt genomic subgroups distinguishing a stable group (0-5 DNA aberrations) and an unstable group (>5 DNA aberrations), showing that the genomic unstable group had a shorter OS (P=0.05). We therefore conclude that specific chromosomal abnormalities, such as gains of 8q24.21 (MYC) and losses of 9p21.3 (CDKN2A, CDKN2B, and MTAP) and 10q26qter (MGMT and EBF3) may have an important role in prognosis. In addition, we describe the MFt genomic instability profile, which, to our knowledge, has not been reported earlier. Oligonucleòtids Genòmica Micosi Tumors Marcadors genètics Oligonucleotides Genomics Mycosis Tumors Genetic markers Oligonucleotide array-CGH identifies genomic subgroups and prognostic markers for tumor stage mycosis fungoides