2026-04-17T06:14:41Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1200392025-12-04T22:54:54Zcom_2072_1057col_2072_478782col_2072_478917
RECERCAT
author
Vinardell Martínez-Hidalgo, Ma. Pilar
author
Llanas Marco, Hector
author
Marics, Laura
author
Mitjans Arnal, Montserrat
2018-02-20T14:26:24Z2018-02-20T14:26:24Z2017-03-042018-02-20T14:26:24Z
This study was designed to determine whether nano-sized ZnO has the potential to cause acute cutaneous irritation using cultured HaCaT keratinocytes and a human skin equivalent as in vitro models, compared to non-nanomaterials. Commercial nano ZnO with different sizes (50 nm and 100 nm) was characterized by dynamic light scattering (DLS) and microscopy (SEM) in different media. Nano ZnO reduced the cell viability of HaCaT in a dose-dependent and time-dependent manner, in a similar way to macro ZnO. However, the 3D-epidermis model revealed no irritation at 1 mg/mL after 24 h of exposure. In conclusion, nano-sized ZnO does not irritate skin, in a similar manner to non-nano ZnO.
cc-by (c) Vinardell Martínez-Hidalgo, Ma. Pilar et al., 2017 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess
Òxid de zinc
Malalties de la pell
Zinc oxide
Skin diseases
In vitro comparative skin irritation induced by micro and nano zinc oxide
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion