2026-04-13T02:49:18Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1190142025-12-05T05:45:26Zcom_2072_1057col_2072_478824col_2072_478858col_2072_478917
RECERCAT
author
Lee, Seung-Tae
author
Muench, Marcus O.
author
Fomin, Marina E.
author
Xiao, Jianqiao
author
Zhou, Mi
author
Smith, Adam de
author
Martín-Subero, José Ignacio
author
Heath, Simon C.
author
Houseman, E.Andres
author
Roy, Ritu
author
Wrensch, Margaret
author
Wiencke, John K.
author
Metayer, Catherine
author
Wiemels, Joseph L.
2018-01-12T15:12:21Z2018-01-12T15:12:21Z2015-03-112018-01-12T15:12:21Z
We investigated DNA methylomes of pediatric B-cell acute lymphoblastic leukemias (B-ALLs) using whole-genome bisulfite sequencing and high-definition microarrays, along with RNA expression profiles. Epigenetic alteration of B-ALLs occurred in two tracks: de novo methylation of small functional compartments and demethylation of large inter-compartmental backbones. The deviations were exaggerated in lamina-associated domains, with differences corresponding to methylation clusters and/or cytogenetic groups. Our data also suggested a pivotal role of polycomb and CTBP2 in de novo methylation, which may be traced back to bivalency status of embryonic stem cells. Driven by these potent epigenetic modulations, suppression of polycomb target genes was observed along with disruption of developmental fate and cell cycle and mismatch repair pathways and altered activities of key upstream regulators.
cc-by-nc (c) Lee, Seung-Tae et al., 2015 http://creativecommons.org/licenses/by-nc/3.0/es info:eu-repo/semantics/openAccess
Leucèmia
Epigenètica
Cèl·lules mare embrionàries
Leukemia
Epigenetics
Embryonic stem cells
Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures.
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion