2026-04-17T05:40:54Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1188472025-11-19T10:41:59Zcom_2072_1057col_2072_478777col_2072_478815col_2072_478816col_2072_478917
RECERCAT
author
Ettcheto Arriola, Miren
author
Sánchez-López, E. (Elena)
author
Pons, Laura
author
Busquets Figueras, Oriol
author
Olloquequi, Jordi
author
Beas Zárate, Carlos
author
Pallàs i Llibería, Mercè, 1964-
author
García López, María Luisa
author
Auladell i Costa, M. Carme
author
Folch, Jaume
author
Camins Espuny, Antoni
2017-12-21T14:20:21Z2017-12-21T14:20:21Z2017-06-152017-12-21T14:20:21Z
The aim of the present study is to elucidate the neuronal pathways associated to NSAIDs causing a reduction of the risk and progression of Alzheimer's disease. The research was developed administering the active enantiomer of ibuprofen, dexibuprofen (DXI), in order to reduce associated gastric toxicity. DXI was administered from three to six-month-old female APPswe/PS1dE9 mice as a model of familial Alzheimer's disease. DXI treatment reduced the activation of glial cells and the cytokine release involved in the neurodegenerative process, especially TNFα. Moreover, DXI reduced soluble β-amyloid (Aβ1-42) plaque deposition by decreasing APP, BACE1 and facilitating Aβ degradation by enhancing insulin-degrading enzyme. DXI also decreased TAU hyperphosphorylation inhibiting c-Abl/CABLES/p-CDK5 activation signal pathway and prevented spatial learning and memory impairment in transgenic mice. Therefore, chronic DXI treatment could constitute a potential AD-modifying drug, both restoring cognitive functions and reversing multiple brain neuropathological hallmarks.
cc-by-nc-nd (c) Elsevier B.V., 2017 http://creativecommons.org/licenses/by-nc-nd/3.0/es info:eu-repo/semantics/openAccess
Malaltia d'Alzheimer
Hipocamp (Cervell)
Receptors d'insulina
Mitocondris
Medicaments
Alzheimer's disease
Hippocampus (Brain)
Insulin receptors
Mitochondria
Drugs
Dexibuprofen prevents neurodegeneration and cognitive decline in APPswe/PS1dE9 through multiple signaling pathways.
info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion