2026-04-17T11:54:03Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1187132025-12-04T19:28:02Zcom_2072_1057col_2072_478858col_2072_478917col_2072_478921

00925njm 22002777a 4500 dc Vasconcelos-Moreno, Mirela P. author Bücker, Joana author Bürke, Kelen P. author Czepielewski, Leticia author Santos, Barbara T. author Fijtman, Adam author Passos, Ives C. author Kunz, Mauricio author Bonnín Roig, Caterina del Mar author Vieta i Pascual, Eduard, 1963- author Kapczinski, Flávio author Rosa, Adriane Ribeiro author Kauer-Sant'Anna, Marcia author 2017-12-13T17:14:56Z 2017-12-13T17:14:56Z 2016-04-19 2017-12-13T17:14:56Z Objective:: To assess cognitive performance and psychosocial functioning in patients with bipolar disorder (BD), in unaffected siblings, and in healthy controls. Methods:: Subjects were patients with BD (n=36), unaffected siblings (n=35), and healthy controls (n=44). Psychosocial functioning was accessed using the Functioning Assessment Short Test (FAST). A sub-group of patients with BD (n=21), unaffected siblings (n=14), and healthy controls (n=22) also underwent a battery of neuropsychological tests: California Verbal Learning Test (CVLT), Stroop Color and Word Test, and Wisconsin Card Sorting Test (WCST). Clinical and sociodemographic characteristics were analyzed using one-way analysis of variance or the chi-square test; multivariate analysis of covariance was used to examine differences in neuropsychological variables. Results:: Patients with BD showed higher FAST total scores (23.90±11.35) than healthy controls (5.86±5.47; p < 0.001) and siblings (12.60±11.83; p 0.001). Siblings and healthy controls also showed statistically significant differences in FAST total scores (p = 0.008). Patients performed worse than healthy controls on all CVLT sub-tests (p < 0.030) and in the number of correctly completed categories on WCST (p = 0.030). Siblings did not differ from healthy controls in cognitive tests. Conclusion:: Unaffected siblings of patients with BD may show poorer functional performance compared to healthy controls. FAST scores may contribute to the development of markers of vulnerability and endophenotypic traits in at-risk populations. Trastorn bipolar Trastorns de la cognició Neuropsicologia Manic-depressive illness Cognition disorders Neuropsychology Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls