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ApoA-I Mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer. Cedó Giné, Lídia García León, Annabel Baila Rueda, Lucía Santos, David Grijalva, Victor Martínez Cignoni, Melanie Raquel Carbó, José M. Metso, Jari López Vilaró, Laura Zorzano Olarte, Antonio Valledor Fernández, Annabel Cenarro, Ana Jauhiainen, Matti Lerma, Enrique Fogelman, Alan M. Reddy, Srinivasa T. Escolà Gil, Joan Carles Blanco-Vaca, Francisco Càncer de mama Hiperlipoproteïnes Ratolins transgènics Pèptids Breast cancer High density lipoproteins Transgenic mice Peptides Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with regard to the relationship between apolipoprotein (apo) A-I and breast cancer. We aimed to determine the effects of human apoA-I overexpression and administration of specific apoA-I mimetic peptide (D-4F) on tumour progression by using mammary tumour virus-polyoma middle T-antigen transgenic (PyMT) mice as a model of inherited breast cancer. Expression of human apoA-I in the mice did not affect tumour onset and growth in PyMT transgenic mice, despite an increase in the HDLc level. In contrast, D-4F treatment significantly increased tumour latency and inhibited the development of tumours. The effects of D-4F on tumour development were independent of 27-hydroxycholesterol. However, D-4F treatment reduced the plasma oxidized low-density lipoprotein (oxLDL) levels in mice and prevented oxLDL-mediated proliferative response in human breast adenocarcinoma MCF-7 cells. In conclusion, our study shows that D-4F, but not apoA-I-containing HDL, hinders tumour growth in mice with inherited breast cancer in association with a higher protection against LDL oxidative modification 2017-12-12T15:10:33Z 2017-12-12T15:10:33Z 2016-11-03 2017-12-12T15:10:33Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2045-2322 https://hdl.handle.net/2445/118640 665488 27808249 eng Reproducció del document publicat a: https://doi.org/10.1038/srep36387 Scientific Reports, 2016, vol. 6, p. 36387 https://doi.org/10.1038/srep36387 cc-by (c) Cedó et al., 2016 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess application/pdf application/pdf Nature Publishing Group Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)