2026-04-13T05:56:17Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1186402025-11-19T20:40:55Zcom_2072_1057col_2072_478777col_2072_478781col_2072_478908col_2072_478917

00925njm 22002777a 4500 dc Cedó Giné, Lídia author García León, Annabel author Baila Rueda, Lucía author Santos, David author Grijalva, Victor author Martínez Cignoni, Melanie Raquel author Carbó, José M. author Metso, Jari author López Vilaró, Laura author Zorzano Olarte, Antonio author Valledor Fernández, Annabel author Cenarro, Ana author Jauhiainen, Matti author Lerma, Enrique author Fogelman, Alan M. author Reddy, Srinivasa T. author Escolà Gil, Joan Carles author Blanco-Vaca, Francisco author 2017-12-12T15:10:33Z 2017-12-12T15:10:33Z 2016-11-03 2017-12-12T15:10:33Z Low levels of high-density lipoprotein cholesterol (HDLc) have been associated with breast cancer risk, but several epidemiologic studies have reported contradictory results with regard to the relationship between apolipoprotein (apo) A-I and breast cancer. We aimed to determine the effects of human apoA-I overexpression and administration of specific apoA-I mimetic peptide (D-4F) on tumour progression by using mammary tumour virus-polyoma middle T-antigen transgenic (PyMT) mice as a model of inherited breast cancer. Expression of human apoA-I in the mice did not affect tumour onset and growth in PyMT transgenic mice, despite an increase in the HDLc level. In contrast, D-4F treatment significantly increased tumour latency and inhibited the development of tumours. The effects of D-4F on tumour development were independent of 27-hydroxycholesterol. However, D-4F treatment reduced the plasma oxidized low-density lipoprotein (oxLDL) levels in mice and prevented oxLDL-mediated proliferative response in human breast adenocarcinoma MCF-7 cells. In conclusion, our study shows that D-4F, but not apoA-I-containing HDL, hinders tumour growth in mice with inherited breast cancer in association with a higher protection against LDL oxidative modification Càncer de mama Hiperlipoproteïnes Ratolins transgènics Pèptids Breast cancer High density lipoproteins Transgenic mice Peptides ApoA-I Mimetic administration, but not increased apoA-I-containing HDL, inhibits tumour growth in a mouse model of inherited breast cancer.