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Combating virulence of Gram-negative bacilli by OmpA inhibition Vila Farrés, Xavier Parra Millán, Raquel Sánchez Encinales, Viviana Varese, Monica Ayerbe Algaba, Rafael Bayó Puxan, Núria Guardiola Bagán, Salvador Pachón Ibáñez, María Eugenia Kotev, Martin García Arroyo, Jesús Teixidó Turà, Meritxell Vila Estapé, Jordi Pachón, Jerónimo Giralt Lledó, Ernest Smani, Younes Microorganismes patògens Desenvolupament de medicaments Pathogenic microorganisms Drug development Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling multidrug-resistant bacteria. In this regard, the identification of outer membrane protein A (OmpA) as a key bacterial virulence factor has been a major breakthrough. The use of virtual screening helped us to identify a cyclic hexapeptide AOA-2 that inhibits the adhesion of Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli to host cells and the formation of biofilm, thereby preventing the development of infection in vitro and in a murine sepsis peritoneal model. Inhibition of OmpA offers a strategy as monotherapy to address the urgent need for treatments for infections caused by Gram-negative bacilli. 2017-12-11T14:25:00Z 2017-12-11T14:25:00Z 2017-10-31 2017-12-06T19:00:28Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: http://dx.doi.org/10.1038/s41598-017-14972-y Scientific Reports, 2017, vol. 7, num. 1, p. 14683 http://dx.doi.org/10.1038/s41598-017-14972-y cc by (c) Vila et al., 2017 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Macmillan Publishers Articles publicats en revistes (ISGlobal)