2026-04-13T07:03:30Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1184662025-11-19T11:04:04Zcom_2072_1057col_2072_478917col_2072_478924

00925njm 22002777a 4500 dc González-Sarrías, Antonio author Combet, Emilie author Pinto, Paula author Mena, Pedro author Dall'Asta, Margherita author Garcia Aloy, Mar author Rodriguez-Mateos, Ana author Gibney, Eileen R. author Dumont, Julie author Massaro, Marika author Sánchez Meca, Julio author Morand, Christine author García-Conesa, María Teresa author 2017-12-04T16:03:10Z 2017-12-04T16:03:10Z 2017-07-10 2017-12-04T16:03:10Z Several randomized controlled trials (RCTs) and meta-analyses support the benefits of flavanols on cardiometabolic health, but the factors affecting variability in the responses to these compounds have not been properly assessed. The objectives of this meta-analysis were to systematically collect the RCTs-based-evidence of the effects of flavanol-containing tea, cocoa and apple products on selected biomarkers of cardiometabolic risk and to explore the influence of various factors on the variability in the responses to the consumption of these products. A total of 120 RCTs were selected. Despite a high heterogeneity, the intake of the flavanol-containing products was associated using a random model with changes (reported as standardized difference in means (SDM)) in body mass index (−0.15, p < 0.001), waist circumference (−0.29, p < 0.001), total-cholesterol (−0.21, p < 0.001), LDL-cholesterol (−0.23, p < 0.001), and triacylglycerides (−0.11, p = 0.027), and with an increase of HDL-cholesterol (0.15, p = 0.005). Through subgroup analyses, we showed the influence of baseline-BMI, sex, source/form of administration, medication and country of investigation on some of the outcome measures and suggest that flavanols may be more effective in specific subgroups such as those with a BMI ≥ 25.0 kg/m2, non-medicated individuals or by specifically using tea products. This meta-analysis provides the first robust evidence of the effects induced by the consumption of flavanol-containing tea, cocoa and apple products on weight and lipid biomarkers and shows the influence of various factors that can affect their bioefficacy in humans. Of note, some of these effects are quantitatively comparable to those produced by drugs, life-style changes or other natural products. Further, RCTs in well-characterized populations are required to fully comprehend the factors affecting inter-individual responses to flavanol and thereby improve flavanols efficacy in the prevention of cardiometabolic disorders. Nutrició Te Cacau Pomes Flavonoides Trastorns del metabolisme Malalties cardiovasculars Metaanàlisi Nutrition Tea Cocoa Apples Flavonoids Disorders of metabolism Cardiovascular diseases Meta-analysis A systematic review and meta-analysis of the effects of flavanol-containing tea, cocoa and apple products on selected cardiometabolic risk biomarkers: exploring the factors responsible for variability in their efficacy