2026-04-17T20:31:56Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1183182025-11-19T10:45:08Zcom_2072_1057col_2072_478902col_2072_478917

urn:hdl:2445/118318 Engineered muscle tissues for disease modeling and drug screening applications Mohammandi, Mohammad Hossein Obregón, Raquel Ahadian, Samad Ramon Azcon, Javier Radisic, Milica Músculs Fisiologia experimental Muscles Experimental physiology Animal models have been the main resources for drug discovery and prediction of drugs’ pharmacokinetic responses in the body. However, noticeable drawbacks associated with animal models include high cost, low reproducibility, low physiological similarity to humans, and ethical problems. Engineered tissue models have recently emerged as an alternative or substitute for animal models in drug discovery and testing and disease modeling. In this review, we focus on skeletal muscle and cardiac muscle tissues by first describing their characterization and physiology. Major fabrication technologies (i.e., electrospinning, bioprinting, dielectrophoresis, textile technology, and microfluidics) to make functional muscle tissues are then described. Finally, currently used muscle tissue models in drug screening are reviewed and discussed 2017-11-30T13:38:47Z 2018-11-01T06:10:22Z 2017-11-01 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Versió postprint del document publicat a: http://dx.doi.org/10.2174/1381612823666170215115445 Current Pharmaceutical Design, 2017, vol. 23, p. 2991-3004 (c) Bentham Science Publishers, 2017 info:eu-repo/semantics/openAccess Bentham Science Publishers Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))