2026-04-13T13:32:42Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/1174862025-12-04T23:54:26Zcom_2072_1057col_2072_478917
RECERCAT author Warrington, Nicole M. author Richmond, Rebecca C. author Fenstra, Bjarke author Myhre, Ronny author Gaillard, Romy author Paternoster, Lavinia author Wang, Carol A. author Beaumont, Robin N. author Das, Shikta author Murcia, Mario author Barton, Sheila J. author Espinosa Cardiel, Ana author Thiering, Elisabeth author Atalay, Mustafa author Pitkanen, Niina author Ntalla, Ioanna author Jonsson, Anna E. author Freathy, Rachel M. author Karhunen, Ville author Tiesler, Carla M. T. author Allard, Catherine author Crawford, Andrew author Ring, Susan M. author Melbye, Mads author Magnus, Per author Rivadeneira, Fernando author Skotte, Line author Hansen, Torben author Marsh, Julie A. author Guxens, Mònica author Holloway, John W. author Grallert, Harald author Jaddoe, Vincent W. author Lowe, William L. author Roumeliotaki, Theano author Hattersley, Andrew T. author Lindi, Virpi author Pahkala, Katja author Panoutsopoulou, Kalliope author Standl, Marie author Flexeder, Claudia author Bouchard, Luigi author Nohr, Ellen Aagard author Marina, Loreto Santa author Kogevinas, Manolis author Niinikoski, Harri author Dedoussis, George author Heinrich, Joachim author Reynolds, Rebecca M. author Lakka, Timo author Zeggini, Eleftheria author Raitakari, Olli T. author Chatzi, Leda author Inskip, Hazel M. author Bustamante Pineda, Mariona author Hivert, Marie-France author Jarvelin, Marjo-Riitta author Sorensen, Thorkild I. A. author Pennell, Craig E. author Felix, Janine F. author Jacobsson, Bo author Geller, Frank author Evans, David M. author Lawlor, Debbie A. 2017-11-07T14:15:52Z2017-11-07T14:15:52Z2017-10-092017-11-01T19:00:07Z BACKGROUND: Clinical recommendations to limit gestational weight gain (GWG) imply high GWG is causally related to adverse outcomes in mother or offspring, but GWG is the sum of several inter-related complex phenotypes (maternal fat deposition and vascular expansion, placenta, amniotic fluid and fetal growth). Understanding the genetic contribution to GWG could help clarify the potential effect of its different components on maternal and offspring health. Here we explore the genetic contribution to total, early and late GWG. PARTICIPANTS AND METHODS: A genome-wide association study was used to identify maternal and fetal variants contributing to GWG in up to 10 543 mothers and 16 317 offspring of European origin, with replication in 10 660 mothers and 7561 offspring. Additional analyses determined the proportion of variability in GWG from maternal and fetal common genetic variants and the overlap of established genome-wide significant variants for phenotypes relevant to GWG (e.g. maternal BMI and glucose, birthweight). RESULTS: Approximately 20% of the variability in GWG was tagged by common maternal genetic variants, and the fetal genome made a surprisingly minor contribution to explaining variation in GWG. Variants near the Pregnancy Specific Beta-1-Glycoprotein 5 (PSG5) gene reached genome-wide significance (P=1.71 x 10-8) for total GWG in the offspring genome, but did not replicate. Some established variants associated with increased BMI, fasting glucose and type 2 diabetes were associated with lower early, and higher later GWG. Maternal variants related to higher systolic blood pressure were related to lower late GWG. Established maternal and fetal birthweight variants were largely unrelated to GWG. CONCLUSION: We found a modest contribution of maternal common variants to GWG and some overlap of maternal BMI, glucose and type 2 diabetes variants with GWG. These findings suggest that associations between GWG and later offspring/maternal outcomes may be due to the relationship of maternal BMI and diabetes with GWG.International Journal of Obesity accepted article preview online, 09 October 2017. doi:10.1038/ijo.2017.248. cc-by-nc-sa (c) Warrington et al., 2017 http://creativecommons.org/licenses/by-nc-sa/4.0/ info:eu-repo/semantics/openAccess Genètica mèdica Pes corporal Embaràs Medical genetics Body weight Pregnancy Maternal and fetal genetic contribution to gestational weight gain info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion