2026-04-17T01:07:57Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1142132025-12-05T09:24:44Zcom_2072_1057col_2072_478799col_2072_478916col_2072_478917
RECERCAT
author
Royo, Felix
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Zúñiga García, Patricia
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Torrano, Verónica
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Loizaga Iriarte, Ana
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Sánchez Mosquera, Pilar
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Ugalde-Olano, Aitziber
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González, Esperanza
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Cortazar, Ana Rosa
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Palomo, Laura
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Fernández-Ruiz, Sonia
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Lacasa-Viscasillas, Isabel
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Berdasco, María
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Sutherland, James David
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Barrio, Rosa
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Zabala Letona, Amaia
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Martín-Martín, Natalia
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Arruabarrena-Aristorena, Amaia
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Valcarcel-Jimenez, Lorea
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Caro Maldonado, Alfredo
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Gonzalez-Tampan, Jorge
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Cachi-Fuentes, Guido
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Esteller, Manel
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Aransay, Ana M.
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Unda Urzaiz, Miguel
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Falcón Pérez, Juan Manuel
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Carracedo, Arkaitz
2017-07-24T08:16:25Z2017-07-24T08:16:25Z2016-01-122017-07-24T08:16:25Z
Extracellular vesicles (EV) are emerging structures with promising properties for intercellular communication. In addition, the characterization of EV in biofluids is an attractive source of non-invasive diagnostic, prognostic and predictive biomarkers. Here we show that urinary EV (uEV) from prostate cancer (PCa) patients exhibit genuine and differential physical and biological properties compared to benign prostate hyperplasia (BPH). Importantly, transcriptomics characterization of uEVs led us to define the decreased abundance of Cadherin 3, type 1 (CDH3) transcript in uEV from PCa patients. Tissue and cell line analysis strongly suggested that the status of CDH3 in uEVs is a distal reflection of changes in the expression of this cadherin in the prostate tumor. CDH3 was negatively regulated at the genomic, transcriptional, and epigenetic level in PCa. Our results reveal that uEVs could represent a non-invasive tool to inform about the molecular alterations in PCa.
cc-by (c) Royo, Felix et al., 2016 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess
Càncer de pròstata
Malalties de la pròstata
Marcadors tumorals
Marcadors bioquímics
Anàlisi d'orina
Prostate cancer
Prostatic diseases
Tumor markers
Biochemical markers
Urine analysis
Transcriptomic profiling of urine extracellular vesicles reveals alterations of CDH3 in prostate cancer
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion