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oai:recercat.cat:2445/1134362025-12-05T01:30:49Zcom_2072_1057col_2072_478917

Urinary Arsenic Speciation in Children and Pregnant Women from Spain Signes Pastor, Antonio J. Carey, Manus Vioque, Jesús Navarrete Muñoz, Eva Maria Rodríguez Dehli, Cristina Tardón, Adonina Zubero, Begoña Santa Marina, Loreto Vrijheid, Martine Casas, Maribel Llop, Sabrina Gonzalez Palacios, Sandra Meharg, Andrew A. Embaràs Infants Arsènic Embarassades Pregnancy Children Arsenic Pregnant women Inorganic arsenic (i-As) is a non-threshold human carcinogen that has been associated with several adverse health outcomes. Exposure to i-As is of particular concern among pregnant women, infants and children, as they are specifically vulnerable to the adverse health effects of i-As, and in utero and early-life exposure, even low to moderate levels of i-As, may have a marked effect throughout the lifespan. Ion chromatography-mass spectrometry detection (IC-ICP-MS) was used to analyse urinary arsenic speciation, as an exposure biomarker, in samples of 4-year-old children with relatively low-level arsenic exposure living in different regions in Spain including Asturias, Gipuzkoa, Sabadell and Valencia. The profile of arsenic metabolites in urine was also determined in samples taken during pregnancy (1st trimester) and in the children from Valencia of 7 years old. The median of the main arsenic species found in the 4-year-old children was 9.71 mug/l (arsenobetaine-AsB), 3.97 mug/l (dimethylarsinic acid-DMA), 0.44 mug/l (monomethylarsonic acid-MMA) and 0.35 mug/l (i-As). Statistically significant differences were found in urinary AsB, MMA and i-As according to the study regions in the 4-year-old, and also in DMA among pregnant women and their children. Spearman's correlation coefficient among urinary arsenic metabolites was calculated, and, in general, a strong methylation capacity to methylate i-As to MMA was observed. 2017-07-06T12:17:46Z 2017-07-06T12:17:46Z 2016-08-12 2017-06-21T18:01:27Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2451-9766 https://hdl.handle.net/2445/113436 28553665 eng Reproducció del document publicat a: http://dx.doi.org/10.1007/s12403-016-0225-7 Exposure & Health, 2017, vol. 9, num. 2, p. 105-111 http://dx.doi.org/10.1007/s12403-016-0225-7 info:eu-repo/grantAgreement/EC/FP7/622096/EU//RICENIC info:eu-repo/grantAgreement/EC/FP7/282957/EU//DENAMIC cc by (c) Signes et al., 2016 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess 7 p. application/pdf Springer Articles publicats en revistes (ISGlobal)