2026-04-13T03:09:36Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1113982025-12-05T09:35:07Zcom_2072_1057col_2072_478799col_2072_478916col_2072_478917col_2072_478929

00925njm 22002777a 4500 dc Sanchez-Mut, Jose Vicente author Heyn, Holger author Vidal, Enrique author Moran, Sebastian author Sayols, Sergi author Delgado-Morales, Raul author Schultz, Matthew D. author Ansoleaga, Belén author Garcia Esparcia, Paula author Pons-Espinal, Meritxell author Lagran, M. M. de author Dopazo, Joaquín author Rabano, Alberto author Avila, Jesús author Dierssen, Mara author Lott, I. author Ferrer, Isidro (Ferrer Abizanda) author Ecker, Joseph R. author Esteller, Manel author 2017-05-22T11:43:05Z 2017-05-22T11:43:05Z 2016-01-19 2017-05-22T11:43:05Z Different neurodegenerative disorders often show similar lesions, such as the presence of amyloid plaques, TAU-neurotangles and synuclein inclusions. The genetically inherited forms are rare, so we wondered whether shared epigenetic aberrations, such as those affecting DNA methylation, might also exist. The studied samples were gray matter samples from the prefrontal cortex of control and neurodegenerative disease-associated cases. We performed the DNA methylation analyses of Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease and Alzheimer-like neurodegenerative profile associated with Down's syndrome samples. The DNA methylation landscapes obtained show that neurodegenerative diseases share similar aberrant CpG methylation shifts targeting a defined gene set. Our findings suggest that neurodegenerative disorders might have similar pathogenetic mechanisms that subsequently evolve into different clinical entities. The identified aberrant DNA methylation changes can be used as biomarkers of the disorders and as potential new targets for the development of new therapies. Epigènesi ADN Metilació Malalties neurodegeneratives Sistema nerviós Epigenesis DNA Methylation Neurodegenerative Diseases Nervous system Human DNA methylomes of neurodegenerative diseases show common epigenomic patterns