2026-04-04T02:59:41Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1112272025-12-05T09:22:44Zcom_2072_1057col_2072_478799col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc Rocha, Carmen de la author Pérez-Mojica, J. Eduardo author Zenteno-De León, Silvia author Cervantes-Paz, Braulio author Tristán-Flores, Fabiola E. author Rodríguez-Ríos, Dalia author Molina-Torres, Jorge author Ramírez-Chávez, Enrique author Alvarado-Caudillo, Yolanda author Carmona, F. Javier author Esteller, Manel author Hernández-Rivas, Rosaura author Wrobel, Katarzyna author Wrobel, Kazimierz author Zaina, Silvio author Lund, Gertrud author 2017-05-18T10:18:27Z 2017-05-18T10:18:27Z 2016-05-16 2017-05-18T10:18:27Z Fatty acids (FA) modify DNA methylation in vitro, but limited information is available on whether corresponding associations exist in vivo and reflect any short-term effect of the diet. Associations between global DNA methylation and FAs were sought in blood from lactating infants (LI; n = 49) and adult males (AMM; n = 12) equally distributed across the three conventional BMI classes. AMM provided multiple samples at 2-hour intervals during 8 hours after either a single Western diet-representative meal (post-prandial samples) or no meal (fasting samples). Lipid/glucose profile, HDAC4 promoter and PDK4 5'UTR methylation were determined in AMM. Multiple regression analysis revealed that global (in LI) and both global and PDK4-specific DNA methylation (in AMM) were positively associated with eicosapentaenoic and arachidonic acid. HDAC4 methylation was inversely associated with arachidonic acid post-prandially in AMM. Global DNA methylation did not show any defined within-day pattern that would suggest a short-term response to the diet. Nonetheless, global DNA methylation was higher in normal weight subjects both post-prandially and in fasting and coincided with higher polyunsaturated relative to monounsaturated and saturated FAs. We show for the first time strong associations of DNA methylation with specific FAs in two human cohorts of distinct age, diet and postnatal development stage. Àcids grassos Lípids en la nutrició Trastorns del metabolisme dels lípids Càncer ADN Metilació Fatty acids Lipids in human nutrition Lipid metabolism disorders Cancer DNA Methylation Associations between whole peripheral blood fatty acids and DNA methylation in humans