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oai:recercat.cat:2445/1107682025-12-05T00:49:11Zcom_2072_1057col_2072_478917

Ivermectin to reduce malaria transmission I. Pharmacokinetic and pharmacodynamic considerations regarding efficacy and safety Chaccour, Carlos Hammann, Felix Rabinovich, Regina Malària Medicina tropical Farmacocinètica Malaria Tropical medicine Pharmacokinetics Ivermectin is an endectocide that has been used broadly in single dose community campaigns for the control of onchocerciasis and lymphatic filariasis for more than 30 years. There is now interest in the potential use of ivermectin regimens to reduce malaria transmission, envisaged as community-wide campaigns tailored to transmission patterns and as complement of the local vector control programme. The development of new ivermectin regimens or other novel endectocides will require integrated development of the drug in the context of traditional entomological tools and endpoints. This document examines the main pharmacokinetic and pharmacodynamic parameters of the medicine and their potential influence on its vector control efficacy and safety at population level. This information could be valuable for trial design and clinical development into regulatory and policy pathways. 2017-05-10T13:25:54Z 2017-05-10T13:25:54Z 2017-04-24 2017-05-03T18:01:29Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 1475-2875 https://hdl.handle.net/2445/110768 28434401 eng Reproducció del document publicat a: http://dx.doi.org/10.1186/s12936-017-1801-4 Malaria Journal, 2017, vol. 16, num. 1, p. 161 http://dx.doi.org/10.1186/s12936-017-1801-4 cc by (c) Chaccour et al., 2017 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess 16 p. application/pdf Biomed Central Articles publicats en revistes (ISGlobal)