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oai:recercat.cat:2445/1107672025-11-19T22:28:34Zcom_2072_1057col_2072_478917

urn:hdl:2445/110767 Ivermectin to reduce malaria transmission III. Considerations regarding regulatory and policy pathways Chaccour, Carlos Rabinovich, Regina Malària Medicina tropical Malaria Tropical medicine Vector control is a task previously relegated to products that (a) kill the mosquitoes directly at different stages (insecticides, larvicides, baited traps), or (b) avoid/reduce human-mosquito contact (bed nets, repellents, house screening), thereby reducing transmission. The potential community-based administration of the endectocide ivermectin with the intent to kill mosquitoes that bite humans, and thus reduce malaria transmission, offers a novel approach using a well-known drug, but additional steps are required to address technical, regulatory and policy gaps. The proposed community administration of this drug presents dual novel paradigms; first, indirect impact on the community rather than on individuals, and second, the use of a drug for vector control. In this paper, the main questions related to the regulatory and policy pathways for such an application are identified. Succinct answers are proposed for how the efficacy, safety, acceptability, cost-effectiveness and programmatic suitability could result in regulatory approval and ultimately policy recommendations on the use of ivermectin as a complementary vector control tool. 2017-05-10T13:25:01Z 2017-05-10T13:25:01Z 2017-04-24 2017-05-03T18:00:19Z info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Reproducció del document publicat a: http://dx.doi.org/10.1186/s12936-017-1803-2 Malaria Journal, 2017, vol. 16, num. 1, p. 162 http://dx.doi.org/10.1186/s12936-017-1803-2 cc by (c) Chaccour et al., 2017 http://creativecommons.org/licenses/by/3.0/es/ info:eu-repo/semantics/openAccess Biomed Central Articles publicats en revistes (ISGlobal)