2026-04-17T08:04:31Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1100022025-12-04T21:42:55Zcom_2072_1057col_2072_478917col_2072_478933
RECERCAT
author
Prades, Amparo
author
Núñez-Pertíñez, Samuel
author
Riera i Escalé, Antoni
author
Verdaguer i Espaulella, Xavier
2017-04-24T12:27:09Z2017-03-312017-04-24T12:27:09Z
The synthesis of P-stereogenic bisphosphine ligands starting from a phosphinous acid chiral synthon and hydrazine is reported. The dialkylation of the hydrazine backbone yielded atropo- and nitrogeninversion isomers which are in slow exchange. The crystallization of one of the isomers allowed us to study the reaction kinetics of the equilibria. The new ligands were tested in the Rh catalysed asymmetric hydrogenation of various benchmark substrates attaining up to 99% ee.
CC BY (c) Prades, Amparo et al., 2017 http://creativecommons.org/licenses/by/3.0/ info:eu-repo/semantics/openAccess
Lligands
Catàlisi asimètrica
Ligands
Enantioselective catalysis
P-Stereogenic bisphosphines with a hydrazine backbone: from N-N atropoisomerism to double nitrogen inversion
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion