2026-04-14T03:46:30Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1100022025-12-04T21:42:55Zcom_2072_1057col_2072_478917col_2072_478933

00925njm 22002777a 4500 dc Prades, Amparo author Núñez-Pertíñez, Samuel author Riera i Escalé, Antoni author Verdaguer i Espaulella, Xavier author 2017-04-24T12:27:09Z 2017-03-31 2017-04-24T12:27:09Z The synthesis of P-stereogenic bisphosphine ligands starting from a phosphinous acid chiral synthon and hydrazine is reported. The dialkylation of the hydrazine backbone yielded atropo- and nitrogeninversion isomers which are in slow exchange. The crystallization of one of the isomers allowed us to study the reaction kinetics of the equilibria. The new ligands were tested in the Rh catalysed asymmetric hydrogenation of various benchmark substrates attaining up to 99% ee. Lligands Catàlisi asimètrica Ligands Enantioselective catalysis P-Stereogenic bisphosphines with a hydrazine backbone: from N-N atropoisomerism to double nitrogen inversion