2026-04-17T02:35:55Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1090552025-12-05T14:51:07Zcom_2072_1057col_2072_478917col_2072_478921col_2072_478924

00925njm 22002777a 4500 dc Garcia Aloy, Mar author Llorach, Rafael author Urpí Sardà, Mireia author Tulipani, Sara author Estruch Riba, Ramon author Martínez-González, Miguel Ángel, 1957- author Corella Piquer, Dolores author Fitó Colomer, Montserrat author Ros Rahola, Emilio author Salas Salvadó, Jordi author Andrés Lacueva, Ma. Cristina author 2017-03-28T14:50:56Z 2017-03-28T14:50:56Z 2014-07-03 2017-03-28T14:50:56Z The beneficial impact of walnuts on human health has been attributed to their unique chemical composition. In order to characterize the dietary walnut fingerprinting, spot urine samples from two sets of 195 (training) and 186 (validation) individuals were analyzed by an HPLC-q-ToF-MS untargeted metabolomics approach, selecting the most discriminating metabolites by multivariate data analysis (VIP ≥ 1.5). Stepwise logistic regression analysis was used to design a multimetabolite prediction biomarker model. The global performance of the model and each included metabolite in it was evaluated by receiver operating characteristic curves, using the area under the curve (AUC) values. Dietary exposure to walnuts was characterized by 18 metabolites, including markers of fatty acid metabolism, ellagitannin-derived microbial compounds, and intermediate metabolites of the tryptophan/serotonin pathway. The predictive model of walnut exposure included at least one compound of each class. The AUC (95% CI) for the combined biomarker model was 93.4% (90.1-96.8%) in the training set and 90.2% (85.9-94.6%) in the validation set. The AUCs for individual metabolites were ≤85%. As far as we know, this is the first study proposing a combination of biomarkers of walnut exposure in a population under free-living conditions, as considered in epidemiological studies examining associations between diet and health outcomes. Marcadors bioquímics Cromatografia de líquids d'alta resolució Cuina (Nous) Cuina mediterrània Metabolisme Malalties cardiovasculars Orina Biochemical markers High performance liquid chromatography Cooking (Nuts) Mediterranean cooking Metabolism Cardiovascular diseases Urine Novel multimetabolite prediction of walnut consumption by a urinary biomarker model in a free-living population: the PREDIMED Study