2026-04-13T01:43:46Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/1088132025-12-04T19:12:03Zcom_2072_1057col_2072_478858col_2072_478917col_2072_478921
RECERCAT author Hochhaus, Andreas author Larson, Richard A. author Guilhot, François author Radich, Jerald P. author Branford, Susan author Hughes, Timothy P. author Baccarani, Michele author Deininger, Michael W. author Cervantes Requena, F. author Fujihara, Satoko author Ortmann, Christine E. author Menssen, Hans D. author Kantarjian, Hagop M. author O'Brien, Stephen G. author Druker, Brian J. 2017-03-22T15:59:34Z2017-09-09T22:01:26Z2017-03-092017-03-22T15:59:34Z BACKGROUND Imatinib, a selective BCR-ABL1 kinase inhibitor, improved the prognosis for patients with chronic myeloid leukemia (CML). We conducted efficacy and safety analyses on the basis of more than 10 years of follow-up in patients with CML who were treated with imatinib as initial therapy. METHODS In this open-label, multicenter trial with crossover design, we randomly assigned patients with newly diagnosed CML in the chronic phase to receive either imatinib or interferon alfa plus cytarabine. Long-term analyses included overall survival, response to treatment, and serious adverse events. RESULTS The median follow-up was 10.9 years. Given the high rate of crossover among patients who had been randomly assigned to receive interferon alfa plus cytarabine (65.6%) and the short duration of therapy before crossover in these patients (median, 0.8 years), the current analyses focused on patients who had been randomly assigned to receive imatinib. Among the patients in the imatinib group, the estimated overall survival rate at 10 years was 83.3%. Approximately half the patients (48.3%) who had been randomly assigned to imatinib completed study treatment with imatinib, and 82.8% had a complete cytogenetic response. Serious adverse events that were considered by the investigators to be related to imatinib were uncommon and most frequently occurred during the first year of treatment. CONCLUSIONS Almost 11 years of follow-up showed that the efficacy of imatinib persisted over time and that long-term administration of imatinib was not associated with unacceptable cumulative or late toxic effects. (Funded by Novartis Pharmaceuticals; IRIS ClinicalTrials.gov numbers, NCT00006343 and NCT00333840.) (c) Massachusetts Medical Society, 2017 info:eu-repo/semantics/openAccess Leucèmia mieloide Inhibidors enzimàtics Hematologia Myeloid leukemia Enzyme inhibitors Hematology Long-term outcomes of imatinib treatment for chronic myeloid leukemia. info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion