2026-04-13T07:02:05Zhttps://recercat.cat/oai/request
oai:recercat.cat:2445/1058672025-12-04T20:39:32Zcom_2072_1057col_2072_478800col_2072_478917
RECERCAT author Samino Gené, Sara author Vinaixa Crevillent, Maria author Díaz, Marta author Beltran, Antoni author Rodríguez, Miguel Angel author Mallol, Roger author Heras, Mercedes author Cabré Llobet, Anna author García, Lorena author Canela i Canela, Núria author Zegher, Francis de author Correig Blanchar, Xavier author Ibáñez Toda, Lourdes author Yanes, Oscar 2017-01-19T16:47:27Z2017-01-19T16:47:27Z2015-06-232017-01-19T16:47:27Z Hyperinsulinaemic androgen excess (HIAE) in prepubertal and pubertal girls usually precedes a broader pathological phenotype in adulthood that is associated with anovulatory infertility, metabolic syndrome and type 2 diabetes. The metabolic derangements that determine these long-term health risks remain to be clarified. Here we use NMR and MS-based metabolomics to show that serum levels of methionine sulfoxide in HIAE girls are an indicator of the degree of oxidation of methionine-148 residue in apolipoprotein-A1. Oxidation of apo-A1 in methionine-148, in turn, leads to an impaired maturation of high-density lipoproteins (HDL) that is reflected in a decline of large HDL particles. Notably, such metabolic alterations occur in the absence of impaired glucose tolerance, hyperglycemia and hypertriglyceridemia, and were partially restored after 18 months of treatment with a low-dose combination of pioglitazone, metformin and flutamide. cc-by-nc-nd (c) Samino, Sara et al., 2015 http://creativecommons.org/licenses/by-nc-nd/3.0/es info:eu-repo/semantics/openAccess Adolescents Andrògens Hormones sexuals Lipoproteïnes de la sang Teenagers Androgens Sex hormones Blood lipoproteins Metabolomics reveals impaired maturation of HDL particles in adolescents with hyperinsulinaemic androgen excess. info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion