2026-04-17T19:04:09Zhttps://recercat.cat/oai/requestoai:recercat.cat:2445/1042892025-12-04T19:09:59Zcom_2072_1057col_2072_478858col_2072_478917col_2072_478921
RECERCAT
author
Abulí, Anna
author
Castells Garangou, Antoni
author
Bujanda, Luis
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Lozano Salvatella, Juan José
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Bessa i Caserras, Xavier
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Hernández-Munain, Cristina
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Álvarez Urturi, Cristina
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Pellisé Urquiza, Maria
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Esteban-Jurado, Clara
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Hijona, Elizabeth
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Burón, Andrea
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Macià, Francesc
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Grau Cano, J. (Jaume)
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Guayta, Rafael (Guayta Escolies)
author
Castellví Bel, Sergi
author
Andreu, Montserrat
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Trilla García, Antoni
author
PROCOLON Research Group
2016-11-30T09:34:27Z2016-11-30T09:34:27Z2016-04-142016-11-30T09:34:32Z
Background Common low-penetrance genetic variants have been consistently associated with colorec- tal cancer risk. Aim To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multi- plicity ( 3 adenomas). Methods We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorec- tal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. Results We found that 14 of the analyzed genetic variants showed a statistically significant associa- tion with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with 17 risk alleles. Conclusions Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a sub- group with increased risk for advanced neoplasia and/or multiplicity in the general population.
cc-by (c) Abulí, Anna et al., 2016 http://creativecommons.org/licenses/by/3.0/es info:eu-repo/semantics/openAccess
Càncer colorectal
Genètica humana
Estudi de casos
Mutació (Biologia)
Colonoscòpia
Colorectal cancer
Human genetics
Case studies
Mutation (Biology)
Colonoscopy
Genetic Variants Associated with Colorectal Adenoma Susceptibility
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion