2026-04-18T07:40:00Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1042892025-12-04T19:09:59Zcom_2072_1057col_2072_478858col_2072_478917col_2072_478921

00925njm 22002777a 4500 dc Abulí, Anna author Castells Garangou, Antoni author Bujanda, Luis author Lozano Salvatella, Juan José author Bessa i Caserras, Xavier author Hernández-Munain, Cristina author Álvarez Urturi, Cristina author Pellisé Urquiza, Maria author Esteban-Jurado, Clara author Hijona, Elizabeth author Burón, Andrea author Macià, Francesc author Grau Cano, J. (Jaume) author Guayta, Rafael (Guayta Escolies) author Castellví Bel, Sergi author Andreu, Montserrat author Trilla García, Antoni author PROCOLON Research Group author 2016-11-30T09:34:27Z 2016-11-30T09:34:27Z 2016-04-14 2016-11-30T09:34:32Z Background Common low-penetrance genetic variants have been consistently associated with colorec- tal cancer risk. Aim To determine if these genetic variants are associated also with adenoma susceptibility and may improve selection of patients with increased risk for advanced adenomas and/or multi- plicity ( 3 adenomas). Methods We selected 1,326 patients with increased risk for advanced adenomas and/or multiplicity and 1,252 controls with normal colonoscopy from population-based colorectal cancer screening programs. We conducted a case-control association study analyzing 30 colorec- tal cancer susceptibility variants in order to investigate the contribution of these variants to the development of subsequent advanced neoplasia and/or multiplicity. Results We found that 14 of the analyzed genetic variants showed a statistically significant associa- tion with advanced adenomas and/or multiplicity: the probability of developing these lesions increased with the number of risk alleles reaching a 2.3-fold risk increment in individuals with 17 risk alleles. Conclusions Nearly half of the genetic variants associated with colorectal cancer risk are also related to advanced adenoma and/or multiplicity predisposition. Assessing the number of risk alleles in individuals within colorectal cancer screening programs may help to identify better a sub- group with increased risk for advanced neoplasia and/or multiplicity in the general population. Càncer colorectal Genètica humana Estudi de casos Mutació (Biologia) Colonoscòpia Colorectal cancer Human genetics Case studies Mutation (Biology) Colonoscopy Genetic Variants Associated with Colorectal Adenoma Susceptibility