2026-04-17T13:01:18Zhttps://recercat.cat/oai/request

oai:recercat.cat:2445/1040252025-12-05T13:05:28Zcom_2072_1057col_2072_478798col_2072_478916col_2072_478917

00925njm 22002777a 4500 dc López Sánchez, Marta author Muñoz Esquerre, Mariana author Huertas, Daniel author González-Costello, José author Ribas, Jesús author Manresa, Federico author Dorca i Sargatal, Jordi author Santos Pérez, Salud author 2016-11-21T12:39:11Z 2016-11-21T12:39:11Z 2013-06-27 2016-11-21T12:39:16Z Background: a subclinical left ventricle diastolic dysfunction (LVDD) has been described in patients with chronic obstructive pulmonary disease (COPD). Objectives: to evaluate the prevalence of LVDD in stable severe COPD patients, to analyze its relationship with exercise capacity and to look for its possible causes (lung hyperinflation, ventricular interdependence or inflammatory mechanisms). Methods: we evaluated 106 consecutive outpatients with severe COPD (FEV1 between 30-50%). Thirty-three (31%) were excluded because of previous heart disease. A pulmonary function test, a 6-minute walking test (6MWT), a Doppler echocardiography test, including diastolic dysfunction parameters, and an analysis of arterial blood gases, NT-proBNP and serum inflammatory markers (CRP, leucocytes), were performed in all patients. Results: the prevalence of LVDD in severe stable COPD patients was 90% (80% type I, n=57, and 10% type II, n=7). A significant association between a lower E/A ratio (higher LVDD type I) and a lower exercise tolerance (6-minute walked distance (6MWD)) was found (r=0.29, p<0.05). The fully adjusted multivariable linear regression model demonstrated that a lower E/A ratio, a DLCO in the quartile 4th and a higher tobacco consumption were associated with a lower 6MWD (76, 57 and 0.7 metres, respectively, p<0.05). A significant correlation between E/A ratio and PaO2 was observed (r=0.26, p<0.05), but not with static lung hyperinflation, inflammation or right ventricle overload parameters. Conclusion: in stable severe COPD patients, the prevalence of LVDD is high and this condition might contribute in their lower exercise tolerance. Hypoxemia could have a concomitant role in their pathogenesis. Malalties pulmonars obstructives cròniques Malalties del pulmó Ventricles cardíacs Malalties cardiovasculars Exercici Chronic obstructive pulmonary diseases Pulmonary diseases Ventricle of heart Cardiovascular diseases Exercise High prevalence of left ventricle diastolic dysfunction in severe COPD associated with a low exercise capacity: A cross-sectional study